ArticleJournal of neurophysiology2010
Activity in the barrel cortex during active behavior and sleep.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Translational difficulties in establishing a pharmacologically induced neurovascular uncoupling model in rats.Scientific reports · 2026Article
- Microglia Modulate Information Processing in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.Brain sciences · 2023Article
- The Role of Potassium and Calcium Currents in the Bistable Firing Transition.bioRxiv : the preprint server for biology · 2023Article
- Short-Term Facilitation of Long-Range Corticocortical Synapses Revealed by Selective Optical Stimulation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia.iScience · 2022Article
- Phasic locus coeruleus activity regulates cortical encoding of salience information.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cortical Dynamics in Presence of Assemblies of Densely Connected Weight-Hub Neurons.Frontiers in computational neuroscience · 2017Article
- Differential wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
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- Cortical balance of excitation and inhibition is regulated by the rate of synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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- Updated energy budgets for neural computation in the neocortex and cerebellum.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency.Molecular brain · 2012Article
- Surround suppression and sparse coding in visual and barrel cortices.Frontiers in neural circuits · 2012Article
- Mapping brain networks in awake mice using combined optical neural control and fMRI.Journal of neurophysiology · 2011Article
- Assessing neuronal interactions of cell assemblies during general anesthesia.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2011Article
- Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep?Current topics in medicinal chemistry · 2011Review
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The rate at which neurons fire has wide-reaching implications for the coding schemes used by neural systems. Despite the extensive use of the barrel cortex as a model system, relatively few studies have examined the rate of sensory activity in single neurons in freely moving animals. We examined the activity of barrel cortex neurons in behaving animals during sensory cue interaction, during non-stimulus-related activity, during various states of sleep, and during the administration of isoflurane. The activity of regular-spiking units (RSUs: predominantly excitatory neurons) and fast spiking units (FSUs: a subtype of inhibitory interneurons) was examined separately. We characterized activity by calculating neural firing rates, because several reports have emphasized the low firing rates in this system, reporting that both baseline activity and stimulus evoked activity is <1 Hz. We report that, during sensory cue interaction or non-stimulus-related activity, the majority of RSUs in rat barrel cortex fired at rates significantly >1 Hz, with 27.4% showing rates above 10 Hz during cue interaction. Even during slow wave sleep, which had the lowest mean and median firing rates of any nonanesthetized state observed, 80.0% of RSUs fired above 1 Hz. During all of the nonanesthetized states observed 100% of the FSUs fired well above 1 Hz. When rats were administered isoflurane and at a depth of anesthesia used in standard in vivo electrophysiological preparations, all of the RSUs fired below 1 Hz. We also found that >80% of RSUs either upmodulated or downmodulated their firing during cue interaction. These data suggest that low firing rates do not typify the output of the barrel cortex during awake activity and during sleep and indicate that sensory coding at both the individual and population levels may be nonsparse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.