Trial reportThe Journal of nutrition2010
Postprandial cysteine/cystine redox potential in human plasma varies with meal content of sulfur amino acids.
Trial report in The Journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Migrasomes constrained by a homologous-targeting photodynamic nanoplatform: enhancing intratumoral CD8Journal of nanobiotechnology · 2026Article
- The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression.Amino acids · 2023Article
- How Aging and Oxidative Stress Influence the Cytopathic and Inflammatory Effects of SARS-CoV-2 Infection: The Role of Cellular Glutathione and Cysteine Metabolism.Antioxidants (Basel, Switzerland) · 2022Review
- The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis.Oxidative medicine and cellular longevity · 2022Review
- The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection.Redox biology · 2021Article
- Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study.Nutrients · 2020Article
- Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults.The Journal of nutrition · 2018Article
- Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions.Molecular & cellular proteomics : MCP · 2014Article
- Multifractal analysis for nutritional assessment.PloS one · 2013Article
- Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells.Cellular and molecular neurobiology · 2013Article
- Characterization of plasma thiol redox potential in a common marmoset model of aging.Redox biology · 2013Article
- Intestinal redox biology and oxidative stress.Seminars in cell & developmental biology · 2012Review
- Redox outside the box: linking extracellular redox remodeling with intracellular redox metabolism.The Journal of biological chemistry · 2012Review
- Redox biology of the intestine.Free radical research · 2011Review
- Oxidative stress is associated with impaired arterial elasticity.Atherosclerosis · 2011Article
- A sulfur amino acid-free meal increases plasma lipids in humans.The Journal of nutrition · 2011Article
- Cysteine/cystine redox signaling in cardiovascular disease.Free radical biology & medicine · 2011Review
- Amino acid composition in parenteral nutrition: what is the evidence?Current opinion in clinical nutrition and metabolic care · 2011Review
- Redox sensing: orthogonal control in cell cycle and apoptosis signalling.Journal of internal medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Few data are available on plasma redox responses to sulfur amino acid (SAA) loads. In this study, we had 2 aims: to determine whether the SAA content of a meal affected postprandial plasma cysteine (Cys), cystine (CySS), or redox potential (E(h)CySS) in humans and whether SAA intake level (adequate or inadequate) in the days preceding the meal challenge affected these postprandial levels. Eight healthy individuals aged 18-36 y were equilibrated for 3 d to adequate SAA, fed chemically defined meals without SAA for 5 d (inadequate SAA) and then fed isoenergetic, isonitrogenous meals with adequate SAA for 5 d. On the first and last days with the chemically defined meals, a morning meal containing 60% of the daily food intake was given, and plasma Cys, CySS, and E(h)CySS were determined over an 8-h postprandial time course. Following equilibration to adequate intake, provision of the meal with SAA resulted in increased plasma Cys and CySS concentrations and more reduced plasma E(h)CySS compared with the postprandial values following the same meal without SAA. Equilibration to inadequate SAA intake for the days preceding the meal challenge did not affect this response. The magnitude of the difference in postprandial plasma E(h)CySS (10 mV) due to meal content of SAA was comparable to those which alter physiologic signaling and/or are associated with disease risk. Consequently, the SAA content of meals could affect physiologic signaling and associated disease mechanisms in the postprandial period by changes in Cys, CySS, or E(h)CySS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.