ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- How neuronal morphology impacts the synchronisation state of neuronal networks.PLoS computational biology · 2024Article
- On the Role of Arkypallidal and Prototypical Neurons for Phase Transitions in the External Pallidum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors.PLoS computational biology · 2019Article
- Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network.Frontiers in computational neuroscience · 2019Article
- Effect of Phase Response Curve Shape and Synaptic Driving Force on Synchronization of Coupled Neuronal Oscillators.Neural computation · 2017Article
- Neurons as oscillators.Journal of neurophysiology · 2016Review
- Differential effects of conductances on the phase resetting curve of a bursting neuronal oscillator.Journal of computational neuroscience · 2015Article
- On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro.PLoS computational biology · 2015Article
- Origins and suppression of oscillations in a computational model of Parkinson's disease.Journal of computational neuroscience · 2014Article
- Modulation of motoneuron firing by recurrent inhibition in the adult rat in vivo.Journal of neurophysiology · 2014Article
- Transgenic mouse lines subdivide external segment of the globus pallidus (GPe) neurons and reveal distinct GPe output pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Spectral reconstruction of phase response curves reveals the synchronization properties of mouse globus pallidus neurons.Journal of neurophysiology · 2013Article
- Active decorrelation in the basal ganglia.Neuroscience · 2013Review
- Synchrony in Parkinson's disease: importance of intrinsic properties of the external globus pallidus.Frontiers in systems neuroscience · 2013Review
- Nonlinear Dynamics of Neuronal Excitability, Oscillations, and Coincidence Detection.Communications on pure and applied mathematics · 2013Article
- Spike width and frequency alter stability of phase-locking in electrically coupled neurons.Biological cybernetics · 2013Article
- Optimal number of stimulation contacts for coordinated reset neuromodulation.Frontiers in neuroengineering · 2013Article
- Impact of neuronal heterogeneity on correlated colored noise-induced synchronization.Frontiers in computational neuroscience · 2013Article
- Desynchronization boost by non-uniform coordinated reset stimulation in ensembles of pulse-coupled neurons.Frontiers in computational neuroscience · 2013Article
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3 authors.
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Abstract
Synchronization of globus pallidus (GP) neurons and cortically entrained oscillations between GP and other basal ganglia nuclei are key features of the pathophysiology of Parkinson's disease. Phase response curves (PRCs), which tabulate the effects of phasic inputs within a neuron's spike cycle on output spike timing, are efficient tools for predicting the emergence of synchronization in neuronal networks and entrainment to periodic input. In this study we apply physiologically realistic synaptic conductance inputs to a full morphological GP neuron model to determine the phase response properties of the soma and different regions of the dendritic tree. We find that perisomatic excitatory inputs delivered throughout the interspike interval advance the phase of the spontaneous spike cycle yielding a type I PRC. In contrast, we demonstrate that distal dendritic excitatory inputs can either delay or advance the next spike depending on whether they occur early or late in the spike cycle. We find this latter pattern of responses, summarized by a biphasic (type II) PRC, was a consequence of dendritic activation of the small conductance calcium-activated potassium current, SK. We also evaluate the spike-frequency dependence of somatic and dendritic PRC shapes, and we demonstrate the robustness of our results to variations of conductance densities, distributions, and kinetic parameters. We conclude that the distal dendrite of GP neurons embodies a distinct dynamical subsystem that could promote synchronization of pallidal networks to excitatory inputs. These results highlight the need to consider different effects of perisomatic and dendritic inputs in the control of network behavior.
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