ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Development of multisensory processing in ferret parietal cortex.The European journal of neuroscience · 2023Article
- SRF depletion in early life contributes to social interaction deficits in the adulthood.Cellular and molecular life sciences : CMLS · 2022Article
- Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex.Brain, behavior, and immunity · 2018Article
- Effects of developmental alcohol and valproic acid exposure on play behavior of ferrets.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Article
- Developmental alcohol exposure leads to a persistent change on astrocyte secretome.Journal of neurochemistry · 2016Article
- Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression.Molecular neurobiology · 2016Article
- Overexpression of Serum Response Factor in Neurons Restores Ocular Dominance Plasticity in a Model of Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2015Article
- Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses.Alcoholism, clinical and experimental research · 2015Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Glia and neurodevelopment: focus on fetal alcohol spectrum disorders.Frontiers in pediatrics · 2014Review
- The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Long-lasting neural circuit dysfunction following developmental ethanol exposure.Brain sciences · 2013Article
- Overexpression of serum response factor in astrocytes improves neuronal plasticity in a model of early alcohol exposure.Neuroscience · 2012Article
- Early alcohol exposure disrupts visual cortex plasticity in mice.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2012Article
- Serum response factor modulates neuron survival during peripheral axon injury.Journal of neuroinflammation · 2012Article
- Early valproic acid exposure alters functional organization in the primary visual cortex.Experimental neurology · 2011Article
- Serum response factor mediated gene activity in physiological and pathological processes of neuronal motility.Frontiers in molecular neuroscience · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal plasticity deficits underlie many of the neurobehavioral problems seen in fetal alcohol spectrum disorders (FASD). Recently, we showed that third trimester alcohol exposure leads to a persistent disruption in ocular dominance (OD) plasticity. For instance, a few days of monocular deprivation results in a robust reduction of cortical regions responsive to the deprived eye in normal animals, but not in ferrets exposed early to alcohol. This plasticity deficit can be reversed if alcohol-exposed animals are treated with a phosphodiesterase type 1 (PDE1) inhibitor during the period of monocular deprivation. PDE1 inhibition can increase cAMP and cGMP levels, activating transcription factors such as the cAMP response element binding protein (CREB) and the serum response factor (SRF). SRF is important for many plasticity processes such as LTP, LTD, spine motility, and axonal pathfinding. Here we attempt to rescue OD plasticity in alcohol-treated ferrets using a Sindbis viral vector to express a constitutively active form of SRF during the period of monocular deprivation. Using optical imaging of intrinsic signals and single-unit recordings, we observed that overexpression of a constitutively active form of SRF, but neither its dominant-negative nor GFP, restored OD plasticity in alcohol-treated animals. Surprisingly, this restoration was observed throughout the extent of the primary visual cortex and most cells infected by the virus were positive for GFAP rather than NeuN. This finding suggests that overexpression of SRF in astrocytes may reduce the deficits in neuronal plasticity seen in models of FASD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.