ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
A G-protein-coupled neuropeptide Y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- Exposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review.Environmental health insights · 2024Review
- Descending control of nociception in insects?Proceedings. Biological sciences · 2022Review
- The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect.iScience · 2022Article
- Transcriptomic Responses of the Honey Bee Brain to Infection with Deformed Wing Virus.Viruses · 2021Article
- Transcriptome Analysis of NPFR Neurons Reveals a Connection Between Proteome Diversity and Social Behavior.Frontiers in behavioral neuroscience · 2021Article
- Neuropeptide Y tonically inhibits an NMDAR➔AC1➔TRPA1/TRPV1 mechanism of the affective dimension of chronic neuropathic pain.Neuropeptides · 2020Article
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- CREB-B acts as a key mediator of NPF/NO pathway involved in phase-related locomotor plasticity in locusts.PLoS genetics · 2019Article
- Circulating glucose levels inversely correlate withCommunications biology · 2018Article
- Behavioral Aversion to AITC Requires BothFrontiers in neural circuits · 2018Article
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- Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases.Disease models & mechanisms · 2014Review
- Graded encoding of food odor value in the Drosophila brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that human neuropeptide Y (NPY) plays a prominent role in management of stress response and emotion, and higher NPY levels observed in combat-exposed veterans may help coping with posttraumatic stress. Neuropeptide F (NPF), the counterpart of NPY in Drosophila melanogaster, also displays parallel activities, including promotion of resilience to diverse stressors and prevention of uncontrolled aggressive behavior. However, it remains unclear how NPY family peptides modulate physical and emotional responses to various stressors. Here we show that NPFR1, a G-protein-coupled NPF receptor, exerts an inhibitory effect on larval aversion to diverse stressful stimuli mediated by different subtypes of fly and mammalian transient receptor potential (TRP) family channels. Imaging analysis in larval sensory neurons and cultured human cells showed that NPFR1 attenuates Ca(2+) influx mediated by fly TRPA and rat TRPV1 channels. Our findings suggest that suppression of TRP channel-mediated neural excitation by the conserved NPF/NPFR1 system may be a major mechanism for attaining its broad anti-stress function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.