ArticleThe Journal of general virology2010
Aerosol and nasal transmission of chronic wasting disease in cervidized mice.
Article in The Journal of general virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- The Evolution of Experimental Rodent Models for Prion Diseases.Journal of neurochemistry · 2025Review
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- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Review
- Modeling the Impact of Climate Change on Cervid Chronic Wasting Disease in Semi-Arid South Texas.Frontiers in epidemiology · 2022Article
- Review
- Parkinson's Disease: A Prionopathy?International journal of molecular sciences · 2021Review
- Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids.Scientific reports · 2019Article
- Oral Prion Neuroinvasion Occurs Independently of PrPJournal of virology · 2018Article
- Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling.Journal of clinical microbiology · 2018Article
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice.Journal of virology · 2016Article
- Circulation of prions within dust on a scrapie affected farm.Veterinary research · 2015Article
- Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.Vaccine · 2015Article
- A test for Creutzfeldt-Jakob disease using nasal brushings.The New England journal of medicine · 2014Article
- Protocol for aerosol-free recombinant production and NMR analysis of prion proteins.Journal of biomolecular NMR · 2014Article
- Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.Journal of virology · 2014Article
- Mucosal transmission and pathogenesis of chronic wasting disease in ferrets.The Journal of general virology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known regarding the potential risk posed by aerosolized prions. Chronic wasting disease (CWD) is transmitted horizontally, almost surely by mucosal exposure, and CWD prions are present in saliva and urine of infected animals. However, whether CWD may be transmissible by the aerosol or nasal route is not known. To address this question, FVB mice transgenetically expressing the normal cervid PrP(C) protein [Tg(cerPrP) mice] were exposed to CWD prions by either nose-only aerosol exposure or by drop-wise instillation into the nostrils. Mice were monitored for signs of disease for up to 755 days post-inoculation (p.i.) and by examination of tissues for lesions and PrP(CWD) after necropsy. In particular, nasal mucosa, vomeronasal organ, lungs, lymphoid tissue and the brain were assessed for PrP(CWD) by Western blotting and immunohistochemistry. Six of seven aerosol-exposed Tg(cerPrP) mice developed clinical signs of neurological dysfunction mandating euthanasia between 411 and 749 days p.i. In all these mice, CWD infection was confirmed by detection of spongiform lesions and PrP(CWD) in the brain. Two of nine intranasally inoculated Tg(cerPrP) mice also developed transmissible spongiform encephalopathy associated with PrP(CWD) between 417 and 755 days p.i. No evidence of PrP(CWD) was detected in CWD-inoculated Tg(cerPrP) mice examined at pre-terminal time points. These results demonstrate that CWD can be transmitted by aerosol (as well as nasal) exposure and suggest that exposure via the respiratory system merits consideration for prion disease transmission and biosafety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.