ArticleJournal of virology2010
Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Biographical Feature: Charles Y. Chiu, M.D., Ph.D.Journal of clinical microbiology · 2024Article
- Revolutionized virome research using systems microbiology approaches.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Gut eukaryotic virome in colorectal carcinogenesis: Is that a trigger?Computational and structural biotechnology journal · 2021Review
- 5 challenges in understanding the role of the virome in health and disease.PLoS pathogens · 2020Review
- Infection and Propagation of Astrovirus VA1 in Cell Culture.Current protocols in microbiology · 2019Article
- Frequent detection of Saffold cardiovirus in adenoids.PloS one · 2019Article
- A novel cardiovirus in wild rats.Virology journal · 2018Article
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice.Virology journal · 2016Article
- Intracerebral Inoculation of Mouse-Passaged Saffold Virus Type 3 Affects Cerebellar Development in Neonatal Mice.Journal of virology · 2016Article
- Intracellular localization of Saffold virus Leader (L) protein differs in Vero and HEp-2 cells.Emerging microbes & infections · 2016Article
- The Pathogenesis of Saffold Virus in AG129 Mice and the Effects of Its Truncated L Protein in the Central Nervous System.Viruses · 2016Article
- Saffold virus infection associated with human myocarditis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- Article
- Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections.Neuropathology : official journal of the Japanese Society of Neuropathology · 2015Article
- Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012.Scientific reports · 2015Article
- Picornavirus--host interactions to construct viral secretory membranes.Progress in molecular biology and translational science · 2015Review
- DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression.Journal of neuroimmunology · 2014Article
- Picornavirus infection leading to immunosuppression.Future virology · 2014Article
- Saffold virus is able to productively infect primate and rodent cell lines and induces apoptosis in these cells.Emerging microbes & infections · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Cardioviruses (e.g., Theiler's murine encephalomyelitis virus [TMEV]) are members of the Picornaviridae family that cause myocarditis and encephalitis in rodents. Recently, several studies have identified human cardioviruses, including Saffold virus (SAFV) and a related virus named human TMEV-like cardiovirus (HTCV). At least eight cardiovirus genotypes are now recognized, with SAFV and most strains of HTCV belonging to genotypes 1 and 2, respectively; genotype 2 strains are the most common in the population. Although a genotype 3 cardiovirus has recently been cultured (SAFV-3), the genotype 1 and 2 cardioviruses have been difficult to propagate in vitro, hindering efforts to understand their seroprevalence and pathogenicity. Here we present the isolation and characterization of a genotype 2 human cardiovirus (HTCV-UC6). Notably, successful cultivation of HTCV-UC6 from stool required the addition of cytokine-blocking antibodies to interrupt downstream antiviral pathways. Unlike SAFV-3, HTCV-UC6 exhibited slow replication kinetics and demonstrated only a moderate cytopathic effect. Serologic assays revealed that 91% of U.S. adults carry antibodies to the genotype 2 cardioviruses, of which 80% generate neutralizing antibodies, in agreement with previous data showing that cardiovirus infection is widespread in humans. We also demonstrate an acute cardiovirus seroconversion event in a child with diarrhea and vomiting, thus reporting for the first time evidence linking cardiovirus infection to diarrheal disease in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.