Evidence map›Paper›PMID 20164200›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010

Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.

Tae Hee Han, Kiho Lee, Jin Bong Park, Dongchoon Ahn, Jae-Hyeong Park, Dae-Yong Kim, Javier E Stern, So Yeong Lee, Pan Dong Ryu

Abstract read
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In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

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  8. Sleep-Aids Derived from Natural Products.Biomolecules & therapeutics · 2018
    Review
  9. Overactivity of Liver-Related Neurons in the Paraventricular Nucleus of the Hypothalamus: Electrophysiological Findings inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tae Hee HanLaboratories of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Kiho Lee
Jin Bong Park
Dongchoon Ahn
Jae-Hyeong Park
Dae-Yong Kim
Javier E Stern
So Yeong Lee
Pan Dong Ryu
Chungnam National University · KRAugusta University · USJeonbuk National University · KR

Funding

Altered CNS Intercellular Signaling Mechanisms in Cardiovascular DiseaseR01HL090948 · NHLBI · UNIVERSITY OF CINCINNATI · PI STERN, JAVIER E · 2008 to 2017
$3.0M
NHLBI NIH HHS R01-HL-090948
6 · The paper itself

Abstract

Neuronal activity in the paraventricular nucleus (PVN) is known to be elevated in rats with heart failure. However, the type of neurons involved and the underlying synaptic mechanisms remain unknown. Here we examined spontaneous firing activity and synaptic currents in presympathetic PVN neurons in rats with myocardial infarction (MI), using slice patch clamp combined with the retrograde labeling technique. In PVN neurons projecting to the rostral ventrolateral medulla (PVN-RVLM), MI induced a significant increase in basal firing rate (1.79 to 3.02 Hz, P < 0.05) and a reduction in the frequency of spontaneous (P < 0.05) and miniature (P < 0.01) inhibitory postsynaptic currents (IPSCs). In addition, MI induced an increase in the paired-pulse ratio of evoked IPSCs (P < 0.05). Bicuculline, a GABA(A) receptor antagonist, increased the firing rate of PVN-RVLM neurons in sham-operated (1.21 to 2.74 Hz, P < 0.05) but not MI (P > 0.05) rats. In contrast, in PVN neurons projecting to the intermediolateral horn of the spinal cord (PVN-IML), MI did not induce any significant changes in the basal firing rate and the properties of spontaneous and miniature IPSCs. The properties of spontaneous excitatory postsynaptic currents (EPSCs) were not altered in either neuron group. In conclusion, our results indicate that MI induces an elevation of firing activity in PVN-RVLM but not in PVN-IML neurons and that the elevated firing rate is largely due to a decrease in GABA release. These results provide evidence for a novel target-selective synaptic plasticity in the PVN that is associated with the sympathetic hyperactivity commonly seen in heart failure.

Indexed as

AnimalsBicucullineExcitatory Postsynaptic Potentialsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsMaleMedulla OblongataNeuronsParaventricular Hypothalamic NucleusRatsRats, Sprague-DawleyReceptors, GABA-ASpinal CordBicucullinegamma-Aminobutyric AcidReceptors, GABA-A

Identifiers

PMID20164200
PMCPMC2904143
OpenAlexW2150173819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.