ArticleThe Journal of biological chemistry2010
Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 77 citations in OpenAlex.
- Review
- SNF1/AMPK controls its own localization by phosphorylating its activating kinase Sak1.iScience · 2026Article
- Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells.Nature communications · 2026Article
- TPS5 and TOR signaling components are determinants ofFrontiers in plant science · 2025Article
- Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.Science advances · 2024Article
- DOMAIN OF UNKNOWN FUNCTION581-9 negatively regulates SnRK1 kinase activity.Plant physiology · 2024Article
- MdSnRK1.1 interacts with MdGLK1 to regulate abscisic acid-mediated chlorophyll accumulation in apple.Horticulture research · 2024Article
- GRIK phosphorylates and activates KIN10 which also promotes its degradation.Frontiers in plant science · 2024Article
- Mapping of the plant SnRK1 kinase signalling network reveals a key regulatory role for the class II T6P synthase-like proteins.Nature plants · 2022Article
- Regulatory functions of cellular energy sensor SnRK1 for nitrate signalling through NLP7 repression.Nature plants · 2022Article
- Impaired KIN10 function restores developmental defects in the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant.The New phytologist · 2022Article
- The Role of Sugar Signaling in Regulating Plant Fatty Acid Synthesis.Frontiers in plant science · 2021Review
- KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor.Nature communications · 2020Article
- Overexpression of PpSnRK1α in tomato enhanced salt tolerance by regulating ABA signaling pathway and reactive oxygen metabolism.BMC plant biology · 2020Article
- Peach PpSnRK1 Participates in Sucrose-Mediated Root Growth Through Auxin Signaling.Frontiers in plant science · 2020Article
- Phosphorylation of ADP-Glucose Pyrophosphorylase During Wheat Seeds Development.Frontiers in plant science · 2020Article
- Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development.The Plant cell · 2019Article
- SnRK1 Kinase and the NAC Transcription Factor SOG1 Are Components of a Novel Signaling Pathway Mediating the Low Energy Response Triggered by ATP Depletion.Frontiers in plant science · 2019Article
- Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1.The Plant cell · 2018Article
- Construction of a network describing asparagine metabolism in plants and its application to the identification of genes affecting asparagine metabolism in wheat under drought and nutritional stress.Food and energy security · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 complexes belong to the SNF1/AMPK/SnRK1 protein kinase family that shares an ancestral function as central regulators of metabolism. In A. thaliana, the products of AtSnAK1 and AtSnAK2, orthologous to yeast genes, have been shown to autophosphorylate and to phosphorylate/activate the AtSnRK1.1 catalytic subunit on Thr(175). The phosphorylation of these kinases has been investigated by site-directed mutagenesis and tandem mass spectrometry. The autophosphorylation site of AtSnAK2 was identified as Thr(154), and it was shown to be required for AtSnAK catalytic activity. Interestingly, activated AtSnRK1 exerted a negative feedback phosphorylation on AtSnAK2 at Ser(261) (Ser(260) of AtSnAK1) that was dependent on AtSnAK autophosphorylation. The dynamics of these reciprocal phosphorylation events on the different kinases was established, and structural modeling allowed clarification of the topography of the AtSnAK phosphorylation sites. A mechanism is proposed to explain the observed changes in the enzymatic properties of each kinase triggered by these phosphorylation events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.