Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.Environmental health : a global access science source · 2016
   Pooled it
2. Using systematic reviews for hazard and risk assessment of endocrine disrupting chemicals.Reviews in endocrine & metabolic disorders · 2015
   Pooled it
3. Glyphosate exposure and GM seed rollout unequally reduced perinatal health.Proceedings of the National Academy of Sciences of the United States of America · 2025
   Article
4. Nanoencapsulation of B-toxin from herbal extracts: Targeting HTLV-1 protease and ATLL.Iranian journal of basic medical sciences · 2025
   Article
5. Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.Endocrinology · 2021
   Review
6. The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study.Endocrinology · 2020
   Article
7. WOMEN IN REPRODUCTIVE SCIENCE: Errors and insight: intentional and accidental studies of human chromosome abnormalities.Reproduction (Cambridge, England) · 2019
   Review
8. Endocrine disruptors and the future of toxicology testing - lessons from CLARITY-BPA.Nature reviews. Endocrinology · 2019
   Review
9. Asymmetric development of the male mouse mammary gland and its response to a prenatal or postnatal estrogen challenge.Reproductive toxicology (Elmsford, N.Y.) · 2018
   Article
10. Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure.Environmental health perspectives · 2018
    Article
11. Glyphosate-based herbicides and cancer risk: a post-IARC decision review of potential mechanisms, policy and avenues of research.Carcinogenesis · 2018
    Review
12. Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development.Reproductive toxicology (Elmsford, N.Y.) · 2018
    Article
13. Endocrine disruption in aquatic systems: up-scaling research to address ecological consequences.Biological reviews of the Cambridge Philosophical Society · 2018
    Review
14. Low doses of 17α-ethinyl estradiol alter the maternal brain and induce stereotypies in CD-1 mice exposed during pregnancy and lactation.Reproductive toxicology (Elmsford, N.Y.) · 2017
    Article
15. The mouse mammary gland as a sentinel organ: distinguishing 'control' populations with diverse environmental histories.Environmental health : a global access science source · 2017
    Article
16. Metabolism disrupting chemicals and metabolic disorders.Reproductive toxicology (Elmsford, N.Y.) · 2017
    Review
17. Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals.Journal of epidemiology and community health · 2016
    Review
18. Dietary folate intake and modification of the association of urinary bisphenol A concentrations with in vitro fertilization outcomes among women from a fertility clinic.Reproductive toxicology (Elmsford, N.Y.) · 2016
    Article
19. Environmental endocrine disruptors: Effects on the human male reproductive system.Reviews in endocrine & metabolic disorders · 2015
    Review
20. Assessing dose-response relationships for endocrine disrupting chemicals (EDCs): a focus on non-monotonicity.Environmental health : a global access science source · 2015
    Article

Corrections and comments

• Commented on by
  2010
• Comment on
  In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats.2010

Authors and funding

24 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as