Evidence map›Paper›PMID 20163145›Full record

ArticleAnalytical chemistry2010

Single-molecule spectroscopy and imaging of biomolecules in living cells.

Samuel J Lord, Hsiao-lu D Lee, W E Moerner

Abstract read
In one paragraph

Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Synthetic Stochastic Motion Platform for Testing Single Particle Tracking Microscopes.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2022
    Article
  5. Review
  6. Article
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  9. Article
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  11. Article
  12. Article
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  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel J LordDepartment of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Hsiao-lu D Lee
W E Moerner

Funding

Subcellular architecture of regulatory protein complexes at the bacterial poleR01GM086196 · NIGMS · STANFORD UNIVERSITY · PI MOERNER, WILLIAM E, SHAPIRO, LUCILLE · 2008 to 2015
$4.7M
NIGMS NIH HHS R01 GM086196NIGMS NIH HHS R01GM086196
6 · The paper itself

Abstract

The number of reports per year on single-molecule imaging experiments has grown roughly exponentially since the first successful efforts to optically detect a single molecule were completed over two decades ago. Single-molecule spectroscopy has developed into a field that includes a wealth of experiments at room temperature and inside living cells. The fast growth of single-molecule biophysics has resulted from its benefits in probing heterogeneous populations, one molecule at a time, as well as from advances in microscopes and detectors. This Perspective summarizes the field of live-cell imaging of single biomolecules.

Indexed as

AnimalsBiological TransportBiophysicsCell MembraneCell NucleolusCellular StructuresCytoskeletonEquipment DesignFluorescence Resonance Energy TransferGene ExpressionHumansMicroscopySpectrum Analysis

Identifiers

PMID20163145
PMCPMC2838489

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.