ArticleCroatian medical journal2010
Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.
Article in Croatian medical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis.Rheumatology international · 2016Pooled it
- The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications.Frontiers in pharmacology · 2024Review
- Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate.Frontiers in physiology · 2018Article
- SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration.PloS one · 2015Article
- Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population.PloS one · 2012Article
- Allopurinol, uric acid, and oxidative stress in cardiorenal disease.International urology and nephrology · 2011Review
- The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.Experimental diabetes research · 2011Article
- Uric acid: the past decade.Croatian medical journal · 2010Article
- Estimated frequency of the canine hyperuricosuria mutation in different dog breeds.Journal of veterinary internal medicineArticle
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.
methodsA total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).
resultsThere was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.
conclusionDevelopment of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.
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