ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2010
Cefazolin embedded biodegradable polypeptide nanofilms promising for infection prevention: a preliminary study on cell responses.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Struggling with a cefazolin impregnation protocol of bone chips.Cell and tissue banking · 2025Article
- Recent advances in the application of nanotechnology in joint arthroplasty: a narrative review.Annals of joint · 2025Review
- Nanostructures in Orthopedics: Advancing Diagnostics, Targeted Therapies, and Tissue Regeneration.Materials (Basel, Switzerland) · 2024Review
- A mini-review on the emerging role of nanotechnology in revolutionizing orthopedic surgery: challenges and the road ahead.Frontiers in bioengineering and biotechnology · 2023Review
- Article
- Capsule-Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery.ACS applied materials & interfaces · 2018Article
- Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering.International journal of molecular sciences · 2018Review
- Nanotechnology in orthopedics.Journal of orthopaedics · 2017Review
- Effect of dual delivery of antibiotics (vancomycin and cefazolin) and BMP-7 from chitosan microparticles on Staphylococcus epidermidis and pre-osteoblasts in vitro.Materials science & engineering. C, Materials for biological applications · 2016Article
- An Update into the Application of Nanotechnology in Bone Healing.The open orthopaedics journal · 2016Article
- Differential responses of osteoblasts and macrophages upon Staphylococcus aureus infection.BMC microbiology · 2014Article
- Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells.Stem cells translational medicine · 2013Article
- Unique antimicrobial effects of platelet-rich plasma and its efficacy as a prophylaxis to prevent implant-associated spinal infection.Advanced healthcare materials · 2013Article
- Vancomycin containing PLLA/β-TCP controls MRSA in vitro.Clinical orthopaedics and related research · 2011Article
- Nanoencapsulating living biological cells using electrostatic layer-by-layer self-assembly: platelets as a model.Journal of materials research · 2011Article
- Polypeptide multilayer film co-delivers oppositely-charged drug molecules in sustained manners.Biomacromolecules · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Implant-associated infection is a serious complication in orthopedic surgery, and endowing implant surfaces with antibacterial properties could be one of the most promising approaches for preventing such infection. In this study, we developed cefazolin loaded biodegradable polypeptide multilayer nanofilms on orthopedic implants. We found that the amount of cefazolin released could be tuned. A high local concentration of cefazolin was achieved within the first a few hours and therefore may inhibit bacterial colonization in the critical postimplantation period. The developed cefazolin loaded nanofilms showed their in vitro efficacy against Staphylococcus aureus; the more antibiotics loaded, the longer the nanocoated implant had antibacterial properties. More interestingly, antibiotic-loaded polypeptide multilayer nanofilms also improved osteoblast bioactivity including cell viability and proliferation. These findings suggested that biodegradable polypeptide multilayer nanofilms as antibiotic carriers at the implant/tissue interface are compatible with human cells such as osteoblasts and bactericidal to bacteria such as S. aureus. These characteristics could be promising for preventing implant-associated infection and potentially improving bone healing.
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Registered trials
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