ArticleProtein science : a publication of the Protein Society2010
Discovery and characterization of a mammalian amyloid disaggregation activity.
Article in Protein science : a publication of the Protein Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Broken but not beaten: Challenge of reducing the amyloids pathogenicity by degradation.Journal of advanced research · 2025Review
- Alpha-B-Crystallin Effect on Mature Amyloid Fibrils: Different Degradation Mechanisms and Changes in Cytotoxicity.International journal of molecular sciences · 2020Article
- Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology · 2017Article
- Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.Molecular cell · 2015Article
- Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils.PloS one · 2014Article
- Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes.Protein science : a publication of the Protein Society · 2013Article
- Protein rescue from aggregates by powerful molecular chaperone machines.Nature reviews. Molecular cell biology · 2013Review
- Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils.Journal of the American Chemical Society · 2013Article
- Mechanism of an ATP-independent protein disaggregase: II. distinct molecular interactions drive multiple steps during aggregate disassembly.The Journal of biological chemistry · 2013Article
- Cellular strategies for regulating functional and nonfunctional protein aggregation.Cell reports · 2012Article
- Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.The EMBO journal · 2012Article
- Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.Nature reviews. Drug discovery · 2011Review
- Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes.Molecular biology of the cell · 2011Article
- Cellular strategies of protein quality control.Cold Spring Harbor perspectives in biology · 2011Review
- Article
- Spatial protein quality control and the evolution of lineage-specific ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Article
- Protein folding: The dark side of proteins.Nature · 2010Article
- Article
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Authors and funding
5 authors.
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Abstract
The formation of amyloid, a cross-beta-sheet fibrillar aggregate, is associated with a variety of aging-associated degenerative diseases. Herein, we report the existence of a mammalian amyloid disaggregase activity that is present in all tissues and cell types tested. Homogenates from mammalian tissues and cell lines are able to disaggregate amyloid fibrils composed of amyloid beta (A beta)(1-40) or the 8 kDa plasma gelsolin fragment. The mammalian disaggregase activity is sensitive to proteinase K digestion and can be uncoupled from proteolysis activity using a protease inhibitor cocktail. Amyloid disaggregation and proteolysis activities are remarkably resistant to changes in temperature and pH. Identification and manipulation of the proteins responsible for the amyloid disaggregation/degradation activities offers the possibility of ameliorating aggregation-associated diseases.
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