Trial reportHuman brain mapping2010
Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment.
Trial report in Human brain mapping, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fatigue.Scientific reports · 2019Trial
- Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation.Journal of neurology · 2014Trial
- Functional Connectivity at Rest and During Cognitive Processing in Multiple Sclerosis: A Pilot Magnetoencephalography Study and Systematic Review.Brain sciences · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Effects on Corticospinal Tract Homology of Faremus Personalized Neuromodulation Relieving Fatigue in Multiple Sclerosis: A Proof-of-Concept Study.Brain sciences · 2023Article
- On the Homology of the Dominant and Non-Dominant Corticospinal Tracts: A Novel Neurophysiological Assessment.Brain sciences · 2023Article
- Functional balance at rest of hemispheric homologs assessed via normalized compression distance.Frontiers in neuroscience · 2023Article
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Effects on Motor Control of Personalized Neuromodulation Against Multiple Sclerosis Fatigue.Brain topography · 2021Article
- Investigating the impact of feedback update interval on the efficacy of restorative brain-computer interfaces.Royal Society open science · 2017Article
- Thalamocortical-auditory network alterations following cuprizone-induced demyelination.Journal of neuroinflammation · 2016Article
- Brain Plasticity Effects of Neuromodulation Against Multiple Sclerosis Fatigue.Frontiers in neurology · 2015Article
- Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis.Neuroscience · 2014Article
- Chiropractic management using a brain-based model of care for a 15-year-old adolescent boy with migraine headaches and behavioral and learning difficulties: a case report.Journal of chiropractic medicine · 2013Article
- Diffuse cerebral language representation in tuberous sclerosis complex.Epilepsy research · 2013Article
- Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis.PloS one · 2013Article
- Regional personalized electrodes to select transcranial current stimulation target.Frontiers in human neuroscience · 2013Article
- Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data.Human brain mapping · 2013Article
- Effects of Sensory Interventions on Fatigue in People With Multiple Sclerosis: A Systematic Review.International journal of MS careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Demyelination and axonal damage are pathologic hallmarks of multiple sclerosis (MS), leading to loss of neuronal synchronization, functional disconnection amongst brain relays, and clinical sequelae. To investigate these properties, the primary component of the sensorimotor network was analyzed in mildly disabled Relapsing-Remitting MS patients without sensory symptoms at the time of the investigation. By magnetoencephalography (MEG), the recruitment pattern within the primary sensory (S1) and motor (M1) areas was estimated through the morphology of the early components of somatosensory evoked magnetic fields (SEFs), after evaluating the S1 responsiveness to sensory inputs from the contralateral arm. In each hemisphere, network recruitment properties were correlated with ispilateral thalamus volume, estimated by morphometric techniques upon high-resolution 3D structural magnetic resonance images (MRI). S1 activation was preserved, whereas SEF morphology was strikingly distorted in MS patients, marking a disruption of primary somatosensory network patterning. An unbalance of S1-M1 dynamic recruitment was documented and correlated with the thalamic volume reduction in the left hemisphere. These findings support the model of MS as a disconnection syndrome, with major susceptibility to damage experienced by nodes belonging to more frequently recruited and highly specialized networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.