ArticleParasitology research2010
Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Molecular and Functional Characterization of Inhibitor of Apoptosis Proteins (IAP, BIRP) inFrontiers in microbiology · 2020Article
- Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis.PLoS neglected tropical diseases · 2018Article
- Article
- Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune- activity of macrophage.Parasitology research · 2015Article
- Evaluation of protective immune response in mice by vaccination the recombinant adenovirus for expressing Schistosoma japonicum inhibitor apoptosis protein.Parasitology research · 2014Article
- Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum.Parasitology research · 2014Article
- Schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating Akt expression and upregulating p53 and DR5 expression.PLoS neglected tropical diseases · 2014Article
- Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis.Parasite (Paris, France) · 2014Review
- Current drug targets for helminthic diseases.Parasitology research · 2013Review
- Molecular characterization of a cytokine-induced apoptosis inhibitor from Schistosoma japonicum.Parasitology research · 2012Article
- Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Apoptosis governs the elimination of Schistosoma japonicum from the non-permissive host Microtus fortis.PloS one · 2011Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is a normal process for regulating cellular death of many organisms. Here, we molecularly characterized an inhibitor of apoptosis from Schistosoma japonicum (SjIAP). The transcription of the SjIAP predominantly occurred at the developmental stages in a final host. Functional assay indicated that the SjIAP could inhibit caspase activity either in 293T cell or in schistosome lysates. Additionally, there were differently expressed profiles of the SjIAP in S. japonicum living in different hosts. Our preliminary results suggest that the SjIAP may play important roles in parasitic living and development as well as in the host-parasite interactions, and drug target of SjIAP might be a potential for controlling schistosomiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.