ArticleAnnals of biomedical engineering2010
Airway wall stiffening increases peak wall shear stress: a fluid-structure interaction study in rigid and compliant airways.
Article in Annals of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- How do mechanical forces impact macrophages in the processes of mechanosensing and mechanotransduction?Journal of Zhejiang University. Science. B · 2025Review
- Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024Article
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
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- Functional analysis of the airways after pulmonary lobectomy through computational fluid dynamics.Scientific reports · 2022Article
- Computational fluid dynamics of the airways after left-upper pulmonary lobectomy: A case study.International journal for numerical methods in biomedical engineering · 2021Article
- Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives.The Journal of pathology · 2021Review
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- Identity and novelty in the avian syrinx.Proceedings of the National Academy of Sciences of the United States of America · 2018Review
- Morphological and functional properties of the conducting human airways investigated by in vivo computed tomography and in vitro MRI.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Time Course Changes of the Mechanical Properties of the Iris Pigment Epithelium in a Rat Chronic Ocular Hypertension Model.BioMed research international · 2018Article
- Evaluation of Ventilation-Induced Lung Inflammation Through Multi-Scale Simulations.IEEE journal of translational engineering in health and medicine · 2018Article
- Validation of numerical simulation methods in aortic arch using 4D Flow MRI.Heart and vessels · 2017Article
- Article
- A 4DCT imaging-based breathing lung model with relative hysteresis.Journal of computational physics · 2016Article
- Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation.Bioengineering (Basel, Switzerland) · 2016Article
- Biofilm Cohesive Strength as a Basis for Biofilm Recalcitrance: Are Bacterial Biofilms Overdesigned?Microbiology insights · 2015Article
- A microfluidic device to apply shear stresses to polarizing ciliated airway epithelium using air flow.Biomicrofluidics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
The airflow characteristics in a computed tomography (CT) based human airway bifurcation model with rigid and compliant walls are investigated numerically. An in-house three-dimensional (3D) fluid-structure interaction (FSI) method is applied to simulate the flow at different Reynolds numbers and airway wall stiffness. As the Reynolds number increases, the airway wall deformation increases and the secondary flow becomes more prominent. It is found that the peak wall shear stress on the rigid airway wall can be five times stronger than that on the compliant airway wall. When adding tethering forces to the model, we find that these forces, which produce larger airway deformation than without tethering, lead to more skewed velocity profiles in the lower branches and further reduced wall shear stresses via a larger airway lumen. This implies that pathologic changes in the lung such as fibrosis or remodeling of the airway wall-both of which can serve to restrain airway wall motion-have the potential to increase wall shear stress and thus can form a positive feed-back loop for the development of altered flow profiles and airway remodeling. These observations are particularly interesting as we try to understand flow and structural changes seen in, for instance, asthma, emphysema, cystic fibrosis, and interstitial lung disease.
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