ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2010
Lens epithelial cell apoptosis initiates diabetic cataractogenesis in the Zucker diabetic fatty rat.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association between DNA repair genes (XPD and XRCC1) polymorphisms and susceptibility to age-related cataract (ARC): a meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Pooled it
- Ultra-processed foods consumption and risk of age-related eye diseases: a prospective cohort study with UK biobank.European journal of nutrition · 2024Article
- Glutamate is effective in decreasing opacity formed in galactose-induced cataract model.Scientific reports · 2024Article
- Article
- Effects of Angiotensin Receptor Blockers on Streptozotocin-Induced Diabetic Cataracts.Journal of clinical medicine · 2023Article
- Resveratrol protects against high glucose-induced oxidative damage in human lens epithelial cells by activating autophagy.Experimental and therapeutic medicine · 2021Article
- SUMOylation and deacetylation affect NF-κB p65 activity induced by high glucose in human lens epithelial cells.International journal of ophthalmology · 2019Article
- Article
- Apoptosis Factors of Lens Epithelial Cells Responsible for Cataractogenesis in Vitrectomized Eyes with Silicone Oil Tamponade.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Aquaporin-1 down regulation associated with inhibiting cell viability and inducing apoptosis of human lens epithelial cells.International journal of ophthalmology · 2016Article
- Aldose reductase expression as a risk factor for cataract.Chemico-biological interactions · 2015Article
- Effects of Rosa laevigata Michx. extract on reactive oxygen species production and mitochondrial membrane potential in lens epithelial cells cultured under high glucose.International journal of clinical and experimental medicine · 2015Article
- Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract.PloS one · 2015Article
- Protective effect of tea polyphenol ophthalmic gel on lens epithelial cells in rabbits with silicone oil tamponade after vitrectomy.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Effects of topically applied tocotrienol on cataractogenesis and lens redox status in galactosemic rats.Molecular vision · 2014Article
- Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that damage of lens epithelial cell (LEC) may play an important role in cataract formation. Nitric oxide is involved in cataract development. Here, we investigated the relationship between LEC damage and iNOS expression in the Zucker diabetic fatty (ZDF) rat.
methodsAt 21 weeks of age, the eyes were enucleated and the lens opacity was then examined. Apoptosis were detected by TUNEL assay, and the expression of iNOS and NF-kappaB activation were studied by immunohistochemistry and southwestern histochemistry respectively.
resultsIn 21-week-old male ZDF rats, cataract was developed, TUNEL-positive LECs were markedly increased, and the expression levels of iNOS mRNA and protein were significantly upregulated. The expression pattern of iNOS was closely correlated with apoptotic change of LECs. In addition, advanced glycation end products (AGEs) were accumulated in cytoplasm of LECs. Activated NF-kappaB was mainly detected in nucleus of LECs.
conclusionsThe higher expressions of AGEs, NF-kappaB and iNOS in LECs of diabetic rats suggest that these factors are involved in apoptosis of LEC alterations related to diabetic cataract.
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