ArticleChromosoma2010
Meiotic silencing and fragmentation of the male germline restricted chromosome in zebra finch.
Article in Chromosoma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- The mechanistic and evolutionary diversity of programmed DNA elimination.Nature reviews. Genetics · 2026Review
- Functional Analyses of Histone Methyltransferases in Sea Lamprey Embryos Undergoing Programmed DNA Elimination.bioRxiv : the preprint server for biology · 2026Article
- Sorghum embryos undergoing B chromosome elimination express B-variants of mitotic-related genes.Genome biology · 2025Article
- The Germline-Restricted Chromosome of Male Zebra Finches in Meiotic Prophase I: A Proteinaceous Scaffold and Chromatin Modifications.Animals : an open access journal from MDPI · 2024Article
- Mendelian nightmares: the germline-restricted chromosome of songbirds.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Kinetic Activity of Chromosomes and Expression of Recombination Genes in Achiasmatic Meiosis ofInternational journal of molecular sciences · 2022Article
- Germline-restricted chromosome shows remarkable variation in size among closely related passerine species.Chromosoma · 2022Article
- Delete and survive: strategies of programmed genetic material elimination in eukaryotes.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Occasional paternal inheritance of the germline-restricted chromosome in songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Unravelling the mystery of female meiotic drive: where we are.Open biology · 2021Review
- Programmed DNA Elimination in Vertebrates.Annual review of animal biosciences · 2021Review
- Evolution of B Chromosomes: From Dispensable Parasitic Chromosomes to Essential Genomic Players.Frontiers in genetics · 2021Review
- On the origin and evolution of germline chromosomes in songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Germline-restricted chromosome (GRC) is widespread among songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus.Scientific reports · 2018Article
- Cytomixis in plants: facts and doubts.Protoplasma · 2018Review
- Post-meiotic B chromosome expulsion, during spermiogenesis, in two grasshopper species.Chromosoma · 2017Article
- Germline-specific labeling of the somatic chromosomes by protein phosphatase 2A and histone H3S28 phosphorylation in Acricotopus lucidus.Protoplasma · 2017Article
- Article
- Incomplete meiotic sex chromosome inactivation in the domestic dog.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During male meiotic prophase in mammals, X and Y are in a largely unsynapsed configuration, which is thought to trigger meiotic sex chromosome inactivation (MSCI). In avian species, females are ZW, and males ZZ. Although Z and W in chicken oocytes show complete, largely heterologous synapsis, they too undergo MSCI, albeit only transiently. The W chromosome is already inactive in early meiotic prophase, and inactive chromatin marks may spread on to the Z upon synapsis. Mammalian MSCI is considered as a specialised form of the general meiotic silencing mechanism, named meiotic silencing of unsynapsed chromatin (MSUC). Herein, we studied the avian form of MSUC, by analysing the behaviour of the peculiar germline restricted chromosome (GRC) that is present as a single copy in zebra finch spermatocytes. In the female germline, this chromosome is present in two copies, which normally synapse and recombine. In contrast, during male meiosis, the single GRC is always eliminated. We found that the GRC in the male germline is silenced from early leptotene onwards, similar to the W chromosome in avian oocytes. The GRC remains largely unsynapsed throughout meiotic prophase I, although patches of SYCP1 staining indicate that part of the GRC may self-synapse. In addition, the GRC is largely devoid of meiotic double strand breaks. We observed a lack of the inner centromere protein INCENP on the GRC and elimination of the GRC following metaphase I. Subsequently, the GRC forms a micronucleus in which the DNA is fragmented. We conclude that in contrast to MSUC in mammals, meiotic silencing of this single chromosome in the avian germline occurs prior to, and independent of DNA double strand breaks and chromosome pairing, hence we have named this phenomenon meiotic silencing prior to synapsis (MSPS).
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