ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2007
Zizyphus spina-christi extract protects against aflatoxin B1-initiated hepatic carcinogenicity.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The protective effect of chemical and natural compounds against amiodarone induced toxicity: A systematic review.Biochemistry and biophysics reports · 2026Review
- Computational and Experimental Development of a Novel Multi-Epitope Vaccine Candidate Against Bovine Leukaemia Virus.Veterinary medicine and science · 2026Article
- Ziziphus spina-christi (L.) Leaf Extract Improves Growth, Feed Utilization, Digestive Enzymes and Blood Metabolites in Broiler Chickens.Veterinary medicine and science · 2025Article
- Ethnopharmacology, Biological Evaluation, and Chemical Composition ofAdvances in pharmacological and pharmaceutical sciences · 2022Review
- Protective Effect of Hydroalcoholic Extract of Clove on Thioacetamide-Induced Hepatotoxicity Animal Model: Effects Hydroalcoholic Extract of Clove Against Hepatotoxicity.Galen medical journal · 2022Article
- Article
- Decontamination of aflatoxin B1 in peanuts using various cooking methods.Journal of food science and technology · 2021Article
- Growth performance and reproductive function impairment of glyphosate-based herbicide in male guinea pig (Cavia porcellus).Veterinary medicine and science · 2021Article
- Article
- Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management.Frontiers in microbiology · 2016Review
- Cytotoxicity of different extracts of arial parts of Ziziphus spina-christi on Hela and MDA-MB-468 tumor cells.Advanced biomedical research · 2014Article
- Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet.Toxicology reports · 2014Article
- The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review.Frontiers in microbiology · 2014Review
- Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats.BMC pharmacology & toxicology · 2012Article
- Isoflavones-Enriched Soy Protein Prevents CCL(4)-Induced Hepatotoxicity in Rats.ISRN pharmacology · 2012Article
- Neurophysiological study on possible protective and therapeutic effects of Sidr (Zizyphus spina-christi L.) leaf extract in male albino rats treated with pentylenetetrazol.Saudi journal of biological sciences · 2010Article
- Pharmacological and phytochemical appraisal of selected medicinal plants from jordan with claimed antidiabetic activities.Scientia pharmaceuticaReview
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Aflatoxins (AF), a group of closely related, extremely toxic mycotoxins, produced by Aspergillus flavus and A. parasiticus can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic, and teratogenic to different animal species. Zizyphus spina-christi L. extract was investigated for its antifungal and antimicrobial activities. The aim of the present work was to evaluate the antioxidant activity of the methanol extract of Z. spina-christi L. leaves against the oxidative stress of aflatoxin in rats. Fourty male Sprague-Dawley male rats were divided into four groups including the control group, the group fed aflatoxin-contaminated diet (3 mg/kg diet) and the groups treated with Zizyphus extract (5 mg/kg b.w) alone or in combination with AF for 15 days. Biochemical analysis revealed that treatment with AF resulted in a significant increase in ALT, AST, cholesterol, triglycerides, uric acid, TNFa, LPO, NO and CEA, whereas it decrease significantly GPX and SOD. The histopathological examination of the liver, kidney and testis showed sever histological changes typical to those reported for aflatoxicosis. Animals treated with Zizyphus extract alone or plus AF showed a significant improvement in all biochemical parameters and histological picture of liver, kidney and testis. It could be concluded that Zizyphus extract have a power protective role against aflatoxicosis.
Indexed as
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20161885PMC2816481What OpenQuestion holds
Registered trials
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