ArticlePloS one2010
Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- The Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma.OncoTargets and therapy · 2021Article
- Article
- Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma.Acta neuropathologica communications · 2020Article
- GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.Oncogene · 2019Article
- LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.Journal of experimental & clinical cancer research : CR · 2019Article
- DDM1 Represses Noncoding RNA Expression and RNA-Directed DNA Methylation in Heterochromatin.Plant physiology · 2018Article
- HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.Molecular cancer · 2017Article
- Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.Theranostics · 2017Article
- Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.Cancer research · 2016Article
- Analysis of Chromatin Regulators Reveals Specific Features of Rice DNA Methylation Pathways.Plant physiology · 2016Article
- Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8.Oncogene · 2015Article
- An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin.Journal of molecular biology · 2015Article
- Article
- Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- DNA methylation and differentiation: HOX genes in muscle cells.Epigenetics & chromatin · 2013Article
- DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure.Genome research · 2013Article
- Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.European journal of human genetics : EJHG · 2013Article
- Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.Genome biology · 2013Article
- Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.The Journal of clinical investigation · 2013Article
- DNA methylation and differentiation: silencing, upregulation and modulation of gene expression.Epigenomics · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
DNA cytosine methylation is an important epigenetic mechanism that is involved in transcriptional silencing of developmental genes. Several molecular pathways have been described that interfere with Pol II initiation, but at individual genes the molecular mechanism of repression remains uncertain. Here, we study the molecular mechanism of transcriptional regulation at Hox genes in dependence of the epigenetic regulator Lsh that controls CpG methylation at selected Hox genes. Wild type cells show a nucleosomal deprived region around the transcriptional start site at methylated Hox genes and mediate gene silencing via Pol II stalling. Hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing, in part mediated by the chromodomain protein Chd1. Dynamic modulation of DNA methylation in Lsh-/- and wild type cells demonstrates that catalytically active DNA methyltransferase activity is required for Pol II stalling. Taken together, the data suggests that DNA methylation can be compatible with Pol II binding at selected genes and Pol II stalling can act as alternate mechanism to explain transcriptional silencing associated with DNA methylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.