ArticlePloS one2010
The DIANA-mirExTra web server: from gene expression data to microRNA function.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion.The Journal of biological chemistry · 2012Trial
- PVALB Was Identified as an Independent Prognostic Factor for HCC Closely Related to Immunity, and Its Absence Accelerates Tumor Progression by Regulating NK Cell Infiltration.Journal of hepatocellular carcinoma · 2024Article
- Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition.BMC molecular and cell biology · 2021Article
- Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ.Journal of inflammation research · 2021Article
- Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy.Vaccines · 2020Review
- MMiRNA-ViewerBMC bioinformatics · 2020Article
- Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.Cellular microbiology · 2020Article
- Article
- From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs.Oxidative medicine and cellular longevity · 2018Article
- miR-331-3p and Aurora Kinase inhibitor II co-treatment suppresses prostate cancer tumorigenesis and progression.Oncotarget · 2017Article
- Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer.PloS one · 2017Article
- DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data.Nucleic acids research · 2016Article
- Regulation signature of miR-143 and miR-26 in porcine Salmonella infection identified by binding site enrichment analysis.Molecular genetics and genomics : MGG · 2016Article
- Bioinformatic tools for microRNA dissection.Nucleic acids research · 2016Review
- Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives.Journal of diabetes research · 2016Review
- Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing.PloS one · 2016Article
- Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication.Journal of virology · 2015Article
- MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer.BMC cancer · 2015Article
- [Advances in microRNA and graft-versus-host disease].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.The Journal of clinical investigation · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-throughput gene expression experiments are widely used to identify the role of genes involved in biological conditions of interest. MicroRNAs (miRNA) are regulatory molecules that have been functionally associated with several developmental programs and their deregulation with diverse diseases including cancer. METHODOLOGY/PRINCIPAL
findingsAlthough miRNA expression levels may not be routinely measured in high-throughput experiments, a possible involvement of miRNAs in the deregulation of gene expression can be computationally predicted and quantified through analysis of overrepresented motifs in the deregulated genes 3' untranslated region (3'UTR) sequences. Here, we introduce a user-friendly web-server, DIANA-mirExTra (www.microrna.gr/mirextra) that allows the comparison of frequencies of miRNA associated motifs between sets of genes that can lead to the identification of miRNAs responsible for the deregulation of large numbers of genes. To this end, we have investigated different approaches and measures, and have practically implemented them on experimental data. CONCLUSIONS/SIGNIFICANCE: On several datasets of miRNA overexpression and repression experiments, our proposed approaches have successfully identified the deregulated miRNA. Beyond the prediction of miRNAs responsible for the deregulation of transcripts, the web-server provides extensive links to DIANA-mirPath, a functional analysis tool incorporating miRNA targets in biological pathways. Additionally, in case information about miRNA expression changes is provided, the results can be filtered to display the analysis for miRNAs of interest only.
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