ArticlePloS one2010
Different thymosin Beta 4 immunoreactivity in foetal and adult gastrointestinal tract.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling.Molecular biomedicine · 2026Article
- Thymosin βCells · 2024Review
- Article
- TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms.Nucleic acids research · 2023Article
- Review
- Thymosin β4 dynamics during chicken enteroid development.Molecular and cellular biochemistry · 2021Article
- Progress on the Function and Application of Thymosin β4.Frontiers in endocrinology · 2021Review
- An Investigation on the Therapeutic Effect of Thymosin β4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice.BioMed research international · 2018Article
- Recombinant adeno-associated virus carrying thymosin βWorld journal of gastroenterology · 2017Article
- Thymosin ß4 expression in colorectal polyps and adenomas.Clinics (Sao Paulo, Brazil) · 2013Article
- Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract.European journal of histochemistry : EJH · 2013Article
- STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in rosiglitazone-treated mice.Scientific reports · 2013Article
- MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer.PloS one · 2012Article
- From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions.Journal of cellular and molecular medicine · 2011Article
- Expression pattern of thymosin beta 4 in the adult human liver.European journal of histochemistry : EJH · 2011Article
- Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract.European journal of histochemistry : EJH · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymosin beta 4 (Tbeta(4)) is a member of beta-thymosins, a family of peptides that play essential roles in many cellular functions. A recent study from our group suggested a role for Tbeta(4) in the development of human salivary glands. The aim of this study was to analyze the expression of Tbeta(4) in the human gut during development, and in the adult. METHODOLOGY/PRINCIPAL
findingsImmunolocalization of Tbeta(4) was studied in autoptic samples of tongue, oesophagus, stomach, ileum, colon, liver and pancreas obtained from two human foetuses and two adults. Tbeta(4) appeared unevenly distributed, with marked differences between foetuses and adults. In the stomach, superficial epithelium was positive in foetuses and negative in adults. Ileal enterocytes were strongly positive in the adult and weakly positive in the foetuses. An increase in reactivity for Tbeta(4) was observed in superficial colon epithelium of adults as compared with the foetuses. Striking differences were found between foetal and adult liver: the former showed a very low reactivity for Tbeta(4) while in the adult we observed a strong reactivity in the vast majority of the hepatocytes. A peculiar pattern was found in the pancreas, with the strongest reactivity observed in foetal and adult islet cells. SIGNIFICANCE: Our data show a strong expression of Tbeta(4) in the human gut and in endocrine pancreas during development. The observed differential expression of Tbeta(4) suggests specific roles of the peptide in the gut of foetuses and adults. The observed heterogeneity of Tbeta(4) expression in the foetal life, ranging from a very rare detection in liver cells up to a diffuse reactivity in endocrine pancreas, should be taken into account when the role of Tbeta(4) in the development of human embryo is assessed. Future studies are needed to shed light on the link between Tbeta(4) and organogenesis.
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