ArticlePloS one2010
Sensory regulation of neuroligins and neurexin I in the honeybee brain.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Decoding bee cleptoparasitism through comparative transcriptomics of Coelioxoides waltheriae and its host Tetrapedia diversipes.Scientific reports · 2024Article
- Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster.Scientific reports · 2023Article
- Phenotypic and genetic characterization of AfricanizedFrontiers in insect science · 2023Article
- Roles of neuroligins in central nervous system development: focus on glial neuroligins and neuron neuroligins.Journal of translational medicine · 2022Review
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- The Combined Effects ofBiology · 2020Article
- Article
- Complementary Specializations of the Left and Right Sides of the Honeybee Brain.Frontiers in psychology · 2019Article
- Large-scale transcriptome changes in the process of long-term visual memory formation in the bumblebee, Bombus terrestris.Scientific reports · 2018Article
- Lateralization of Sucrose Responsiveness and Non-associative Learning in Honeybees.Frontiers in psychology · 2018Article
- An Early Sensitive Period Induces Long-Lasting Plasticity in the Honeybee Nervous System.Frontiers in behavioral neuroscience · 2018Article
- Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator.Genome biology and evolution · 2017Article
- Differential Gene Expression Associated with Honey Bee Grooming Behavior in Response to Varroa Mites.Behavior genetics · 2017Article
- Odor Experiences during Preimaginal Stages Cause Behavioral and Neural Plasticity in Adult Honeybees.Frontiers in behavioral neuroscience · 2016Article
- Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees.Scientific reports · 2015Article
- Abundance and significance of neuroligin-1 and glutamate in Hirschsprung's disease.World journal of gastroenterology · 2015Article
- The down-regulation of neuroligin-2 and the correlative clinical significance of serum GABA over-expression in Hirschsprung's disease.Neurochemical research · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurexins and neuroligins, which have recently been associated with neurological disorders such as autism in humans, are highly conserved adhesive proteins found on synaptic membranes of neurons. These binding partners produce a trans-synaptic bridge that facilitates maturation and specification of synapses. It is believed that there exists an optimal spatio-temporal code of neurexin and neuroligin interactions that guide synapse formation in the postnatal developing brain. Therefore, we investigated whether neuroligins and neurexin are differentially regulated by sensory input using a behavioural model system with an advanced capacity for sensory processing, learning and memory, the honeybee. METHODOLOGY/PRINCIPAL
findingsWhole brain expression levels of neuroligin 1-5 (NLG1-5) and neurexin I (NrxI) were estimated by qRT-PCR analysis in three different behavioural paradigms: sensory deprivation, associative scent learning, and lateralised sensory input. Sensory deprived bees had a lower level of NLG1 expression, but a generally increased level of NLG2-5 and NrxI expression compared to hive bees. Bees that had undergone associative scent training had significantly increased levels of NrxI, NLG1 and NLG3 expression compared to untrained control bees. Bees that had lateralised sensory input after antennal amputation showed a specific increase in NLG1 expression compared to control bees, which only happened over time. CONCLUSIONS/SIGNIFICANCE: Our results suggest that (1) there is a lack of synaptic pruning during sensory deprivation; (2) NLG1 expression increases with sensory stimulation; (3) concomitant changes in gene expression suggests NrxI interacts with all neuroligins; (4) there is evidence for synaptic compensation after lateralised injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.