ArticleEuropean journal of inorganic chemistry2009
Towards Antitumor Active trans-Platinum Compounds.
Article in European journal of inorganic chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 157 citations in OpenAlex.
- DNA Polymerase Beta Catalytic and Fidelity Mutations Drive Platinum-Specific Drug Sensitivity.Cancers · 2026Article
- "Non-Classical" Platinum Complexes: A Concise Review.International journal of molecular sciences · 2025Review
- Excited-StateInorganic chemistry · 2025Article
- Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs.Inorganics · 2020Article
- Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression.International journal of molecular sciences · 2019Article
- Platinum(iv) dihydroxido diazidoChemical science · 2019Article
- Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η.The Biochemical journal · 2019Article
- Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes.Royal Society open science · 2018Article
- Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].Chemical communications (Cambridge, England) · 2016Article
- Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering twoChemical science · 2016Article
- The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.Chemical reviews · 2016Review
- Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties.Organometallics · 2014Article
- Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes.Cancer research · 2014Article
- Synthetic methods for the preparation of platinum anticancer complexes.Chemical reviews · 2014Review
- Platinum anticancer drugs and photochemotherapeutic agents: recent advances and future developments.Science progress · 2014Review
- Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis.Journal of the American Chemical Society · 2013Article
- Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights.Journal of medicinal chemistry · 2013Article
- Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation.Journal of inorganic biochemistry · 2013Article
- Rational design of [Co(acacen)L2]+ inhibitors of protein function.Dalton transactions (Cambridge, England : 2003) · 2013Article
- Axial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics.Inorganic chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Substitution of NH(3) by a range of amines in trans-[PtCl(2)(NH(3))(2)] produces compounds with cytotoxicity significantly improved over the parent transplatin and in many cases equivalent to that of cisplatin. This microreview summarizes the chemistry and biology of trans-platinum compounds containing principally planar amines and succinctly reviews the current status of anticancer relevance of the trans-platinum geometry. The nature of bifunctional DNA adducts (intrastrand, interstrand) is remarkably dependent on the nature of the amine. Further, the stability of monofunctional adducts allows for competitive production of DNA-protein crosslinks and overall the results suggest that the trans-platinum chemotype may offer significant potential for design of selective DNA-protein crosslinking agents. A subset of proteins known to bind to DNA modified by trans-platinum is that comprised of zinc fingers - model studies show the potential for formation of heteronuclear thiolate-bridged species as precedent for zinc displacement from the biomolecule.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.