Evidence map›Paper›PMID 20161677›Full record

ReviewExpert review of clinical immunology2010

The link between allergies and eosinophilic esophagitis: implications for management strategies.

Terri F Brown-Whitehorn, Jonathan M Spergel

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. A contemporary look at allergic conjunctivitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Review
  5. Article
  6. Review
  7. IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Terri F Brown-WhitehornDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA. brownte@email.chop.edu
Jonathan M Spergel
University of Pennsylvania · US

Funding

Pimecrolius on T cell Responses in Atopic MarchR01AI062698 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI SPERGEL, JONATHAN MICHEAL · 2005 to 2008
$1.2M
A multi-center clinical trial of 1760 mcg of daily swallowed fluticasone vs. placU01AI088806 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2009 to 2010
$1.1M
NIAID NIH HHS AI064428-01NIAID NIH HHS R01 AI062698NIAID NIH HHS U01 AI088806
6 · The paper itself

Abstract

Eosinophilic esophagitis (EE) has an increased incidence of diagnosis similar to other atopic diseases. We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar features with the importance of T cells and Th2 cytokines for the development of disease. The diseases share underlying inflammation with the potential for remodeling with an increase in TGF-beta expression in asthma and EE. However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids.

Indexed as

Adrenal Cortex HormonesBiological ProductsEosinophiliaEsophagitisFood HypersensitivityHumansHypersensitivityImmunosuppressive AgentsLeukotriene AntagonistsRisk FactorsRisk Reduction BehaviorTh2 CellsT-Lymphocyte SubsetsTreatment OutcomeAdrenal Cortex HormonesBiological ProductsImmunosuppressive AgentsLeukotriene Antagonistsallergic rhinitisasthmaeosinophilic esophagitismurine modelsTh2 cytokines

Identifiers

PMID20161677
PMCPMC2821054
OpenAlexW1997315992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.