Evidence map›Paper›PMID 20161666›Full record

ReviewImmunotherapy2010

Personalized dendritic cell-based tumor immunotherapy.

Nona Janikashvili, Nicolas Larmonier, Emmanuel Katsanis

Abstract readReview
In one paragraph

Review in Immunotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Mesenchymal Stem Cells Beyond Regenerative Medicine.Frontiers in cell and developmental biology · 2020
    Review
  9. Dendritic cells loaded with CD44Oncology letters · 2019
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nona JanikashviliDepartment of Pediatrics, Steele Children's Research Center, Arizona 85724, USA.
Nicolas Larmonier
Emmanuel Katsanis
Children's Center · US

Funding

Immunotherapy for Chronic Myelogenous LeukemiaR01CA104926 · NCI · UNIVERSITY OF ARIZONA · PI KATSANIS, EMMANUEL · 2004 to 2013
$2.4M
NCI NIH HHS R01 CA104926
6 · The paper itself

Abstract

Advances in the understanding of the immunoregulatory functions of dendritic cells (DCs) in animal models and humans have led to their exploitation as anticancer vaccines. Although DC-based immunotherapy has proven clinically safe and efficient to induce tumor-specific immune responses, only a limited number of objective clinical responses have been reported in cancer patients. These relatively disappointing results have prompted the evaluation of multiple approaches to improve the efficacy of DC vaccines. The topic of this review focuses on personalized DC-based anticancer vaccines, which in theory have the potential to present to the host immune system the entire repertoire of antigens harbored by autologous tumor cells. We also discuss the implementation of these vaccines in cancer therapeutic strategies, their limitations and the future challenges for effective immunotherapy against cancer.

Indexed as

AnimalsCancer VaccinesCell DifferentiationDendritic CellsHumansImmune SystemImmunotherapyNeoplasmsCancer Vaccinesanticancer immune responsechaperone proteindendritic cellidiotypepersonalized tumor vaccinetumor lysate

Identifiers

PMID20161666
PMCPMC2819192
OpenAlexW2130364255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.