Evidence map›Paper›PMID 20161507›Full record

ArticleBrain stimulation2009

Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro.

Thomas Radman, Raddy L Ramos, Joshua C Brumberg, Marom Bikson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 338 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
338citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

338 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  19. Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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278 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas RadmanDepartment of Biomedical Engineering, City College of the City University of New York, New York, New York, USA.
Raddy L Ramos
Joshua C Brumberg
Marom Bikson

Funding

VOLTAGE GATING OF ION CHANNELS--SIMULATIONS AND AB INITIO CALCULATIONSS06GM008168 · NIGMS · CITY COLLEGE OF NEW YORK · PI GOVIND, SHUBHA · 1989 to 2010
$17.6M
Corticothalamic Neurons in Sensorimotor CortexR01NS058758 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMONS, DANIEL J. · 2007 to 2010
$1.4M
Mechanisms of Deep Brain Stimulation: Joule Heating and ElectroporationR03NS054783 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2007 to 2008
$153k
NIGMS NIH HHS S06 GM008168NINDS NIH HHS NS054783 01A1NINDS NIH HHS NS058758PHS HHS S06GMOO8168
6 · The paper itself

Abstract

backgroundThe neocortex is the most common target of subdural electrotherapy and noninvasive brain stimulation modalities, including transcranial magnetic stimulation (TMS) and transcranial current simulation (TCS). Specific neuronal elements targeted by cortical stimulation are considered to underlie therapeutic effects, but the exact cell type(s) affected by these methods remains poorly understood.

objectiveWe determined whether neuronal morphology or cell type predicted responses to subthreshold and suprathreshold uniform electric fields.

methodsWe characterized the effects of subthreshold and suprathreshold electrical stimulation on identified cortical neurons in vitro. Uniform electric fields were applied to rat motor cortex brain slices, while recording from interneurons and pyramidal cells across cortical layers, using a whole-cell patch clamp. Neuron morphology was reconstructed after intracellular dialysis of biocytin. Based solely on volume-weighted morphology, we developed a parsimonious model of neuronal soma polarization by subthreshold electric fields.

resultsWe found that neuronal morphology correlated with somatic subthreshold polarization. Based on neuronal morphology, we predict layer V pyramidal neuronal soma to be individually the most sensitive to polarization by optimally oriented subthreshold fields. Suprathreshold electric field action potential threshold was shown to reflect both direct cell polarization and synaptic (network) activation. Layer V/VI neuron absolute electric field action potential thresholds were lower than layer II/III pyramidal neurons and interneurons. Compared with somatic current injection, electric fields promoted burst firing and modulated action potential firing times.

conclusionsWe present experimental data indicating that cortical neuron morphology relative to electric fields and cortical cell type are factors in determining sensitivity to sub- and supra-threshold brain stimulation.

Indexed as

Cell ShapeInterneuronsNeuronsPyramidal CellsAction PotentialsAnimalsCerebral CortexElectric StimulationExcitatory Postsynaptic PotentialsHumansMaleModels, NeurologicalMotor CortexPatch-Clamp TechniquesRatsRats, Sprague-Dawley

Identifiers

PMID20161507
PMCPMC2797131

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.