Evidence map›Paper›PMID 20161419›Full record

ArticleJournal of fluorine chemistry2009

A New Paradigm for Protein Design and Biological Self-Assembly.

Gizem Akçay, Krishna Kumar

Abstract read
In one paragraph

Article in Journal of fluorine chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Pd-Catalyzed Allylation of Imines to Access α-CFEuropean journal of organic chemistry · 2019
    Article
  4. Article
  5. Synthesis of α-CFOrganic & biomolecular chemistry · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Alpha-helical peptide assemblies giving new function to designed structures.Progress in molecular biology and translational science · 2011
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gizem AkçayDepartment of Chemistry, Tufts University, Medford, MA 02155.
Krishna Kumar
Tufts Medical Center · USTufts University · US

Funding

Protein Design Using Unnatural Amino AcidsR01GM065500 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI KUMAR, KRISHNA · 2002 to 2010
$2.5M
Fluorinated Cell Surfaces to Modulate Biological FunctionR01CA125033 · NCI · TUFTS UNIVERSITY MEDFORD · PI KUMAR, KRISHNA · 2008 to 2011
$1.7M
NCI NIH HHS R01 CA125033NIGMS NIH HHS R01 GM065500
6 · The paper itself

Abstract

Very few molecules with biological origins contain the element fluorine. Nature's inability to incorporate fluorine into biomolecules is related to the low concentration of free fluoride in sea and surface water. However, judicious introduction of fluorine into proteins, nucleic acids, lipids and carbohydrates has allowed mechanistic scrutiny of enzyme catalysis, control of protein oligomerization in membranes, clustered display of ligands on surfaces of living cells, and in increasing the protease stability of protein and peptide therapeutics.

Identifiers

PMID20161419
PMCPMC2786179
OpenAlexW2071037690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.