ArticleAdvances in space research : the official journal of the Committee on Space Research (COSPAR)2009
Review of the results from the International C. elegans first experiment (ICE-FIRST).
Article in Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Reduced gravity and muon flux absence affectMicrobiology spectrum · 2026Article
- Cosmic silence and viral noise: transcriptomic crosstalk inFrontiers in microbiology · 2026Article
- A Compact Imaging Platform for ConductingLife (Basel, Switzerland) · 2023Article
- Article
- Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station.NPJ microgravity · 2022Article
- Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight.International journal of molecular sciences · 2021Article
- Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adultiScience · 2021Article
- Intestinal long non-coding RNAs in response to simulated microgravity stress in Caenorhabditis elegans.Scientific reports · 2021Article
- Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity iniScience · 2020Article
- microRNAs involved in the control of toxicity on locomotion behavior induced by simulated microgravity stress in Caenorhabditis elegans.Scientific reports · 2020Article
- Dynamics of entomopathogenic nematode foraging and infectivity in microgravity.NPJ microgravity · 2020Article
- Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans.Scientific reports · 2019Article
- Monte-Carlo dosimetry and real-time imaging of targeted irradiation consequences in 2-cell stage Caenorhabditis elegans embryo.Scientific reports · 2019Article
- Anti-aging effects of long-term space missions, estimated by heart rate variability.Scientific reports · 2019Article
- Article
- Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling.Scientific reports · 2018Article
- ChIP and Chips: Introducing the WormPharm for correlative studies employing pharmacology and genome-wide analyses inJournal of biological methods · 2016Article
- Changes in apoptotic microRNA and mRNA expression profiling in Caenorhabditis elegans during the Shenzhou-8 mission.Journal of radiation research · 2015Article
- The laboratory domestication of Caenorhabditis elegans.Trends in genetics : TIG · 2015Review
- Remote automated multi-generational growth and observation of an animal in low Earth orbit.Journal of the Royal Society, Interface · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In an effort to speed the rate of discovery in space biology and medicine NASA introduced the now defunct model specimen program. Four nations applied this approach with C. elegans in the ICE-FIRST experiment. Here we review the standardized culturing as well as the investigation of muscle adaptation, space biology radiation, and gene expression in response to spaceflight. Muscle studies demonstrated that decreased expression of myogenic transcription factors underlie the decreased expression of myosin seen in flight, a response that would appear to be evolutionarily conserved. Radiation studies demonstrated that radiation damaged cells should be able to be removed via apoptosis in flight, and that C. elegans can be employed as a biological accumulating dosimeter. Lastly, ICE-FIRST gave us our first glimpse at the genomic response to spaceflight, suggesting that altered Insulin and/or TGF-beta signaling in-flight may underlie many of the biological changes seen in response to spaceflight. The fact that the results obtained with C. elegans appear to have strong similarities in human beings suggests that not only will C. elegans prove an invaluable model for understanding the fundamental biological changes seen during spaceflight but that it may also be invaluable for understanding those changes associated with human health concerns in space.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.