ArticleSleep medicine clinics2009
Influence of the Circadian System on Disease Severity.
Article in Sleep medicine clinics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night.Cell metabolism · 2026Observational
- Circadian clock regulation in lung health and disease: molecular mechanisms and therapeutic opportunities.EXCLI journal · 2026Review
- Association of emergency room admissions and weekdays in musculoskeletal medicine: results from a major trauma centre in Germany.BMC emergency medicine · 2025Article
- Perturbation of the circadian clock in chronic diseases involving organ fibrosis.The Journal of clinical investigation · 2025Review
- Prognostic value of circadian rhythm-associated genes in breast cancer.World journal of surgical oncology · 2025Article
- Sleep and allergic diseases among young Chinese adults from the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) cohort.Journal of physiological anthropology · 2024Article
- Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Keeping an eye on circadian time in clinical research and medicine.Clinical and translational medicine · 2022Review
- Planetary sleep medicine: Studying sleep at the individual, population, and planetary level.Frontiers in public health · 2022Review
- Circadian control of human cardiovascular function.Current opinion in pharmacology · 2021Review
- Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma.Journal of asthma and allergy · 2021Article
- Cell Autonomous Circadian Systems and Their Relation to Inflammation.Biomolecules & therapeutics · 2021Review
- Circadian rhythms in adaptive immunity.Immunology · 2020Review
- A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment.Frontiers in physiology · 2019Review
- Role of the circadian system in cardiovascular disease.The Journal of clinical investigation · 2018Review
- The role of the circadian clock system in physiology.Pflugers Archiv : European journal of physiology · 2018Review
- Misalignment with the external light environment drives metabolic and cardiac dysfunction.Nature communications · 2017Article
- Depressive symptoms, quality of sleep, and disease control in women with asthma.Sleep & breathing = Schlaf & Atmung · 2017Article
- Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer.Annals of the American Thoracic Society · 2016Review
- Post-transcriptional control of the mammalian circadian clock: implications for health and disease.Pflugers Archiv : European journal of physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The severity of many diseases varies across the day and night. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, and/or endogenous circadian rhythms in physiology. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease and certain cancers in shift workers. Here we describe the magnitude, relevance and potential biological basis of such daily changes in disease severity and of circadian/behavioral misalignment, and present how these insights may help in the development of appropriate chronotherapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.