ArticleHuman genetics1991
Karyotype peculiarities of human colorectal adenocarcinomas.
Article in Human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure.International journal of medical sciences · 2023Article
- microRNA-mediatedExperimental and therapeutic medicine · 2019Article
- Detailed deletion mapping at chromosome 11q23 in colorectal carcinoma.British journal of cancer · 2000Article
- Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.Journal of clinical pathology · 1996Article
- Numerical aberrations of chromosomes 11 and 17 in colorectal adenocarcinomas.Surgery today · 1996Article
- Loss of heterozygosity on the long arm of chromosome 11 in colorectal tumours.British journal of cancer · 1994Article
- Cytogenetic, oncogenetic, and histopathologic characteristics of colorectal carcinomas with 17p abnormalities.Human genetics · 1992Article
- Chromosome 1 in human colorectal tumors. Cytogenetic research on structural changes and their significance.Human genetics · 1992Article
- Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The data of the chromosome abnormalities in 15 colorectal tumors are presented. Rearrangements of the short arm of chromosome 17, leading to deletions of this arm or its part were noted in 12 tumors; in 2 other cases, one of the homologs of pair 17 was lost. The losses of at least one homolog of other chromosomal pairs were also found: chromosome 18, in 12 out of 13 cases with fully identified numerical abnormalities; chromosome 5, in 6 tumors; chromosome 21, in 5 cases; chromosomes 4, 15, and 22, in 4 cases each. Additional homologs of pair 20 were observed in 6 tumors, extra 8q was found in 5 tumors, and extra 13q in 6 cases. Rearrangements of the short arm of chromosome 1 and the long arm of chromosome 11 characterized 6 tumors each. The data recorded in our series differ from the data of other authors in two respects: the high incidence of the loss of sex chromosomes and the rearrangements of the long arm of chromosome 9. X chromosomes were missing in 4 out of 7 tumors in females, and Y chromosomes were absent in 5 out of 8 tumors in males. The long arm of chromosome 9 was rearranged in 8 cases, in 5 of them the breakpoint being at 9q22. Cytological manifestations of gene amplification (double minutes or multiple microchromosomes) were noted in 6 tumors.
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