Evidence map›Paper›PMID 20160888›Full record

ArticleF1000 biology reports2009

Latest advances in innate antiviral defence.

Aaron Irving, Bryan Rg Williams

Open access · bronzeAbstract read
In one paragraph

Article in F1000 biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Aaron IrvingMonash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, Victoria 3168, Australia.
Bryan Rg Williams
Monash Medical Centre · AU

Funding

TELOMERASE INACTIVATION BY RNASE L SIGNALS CELL DEATHP01CA062220 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI SEN, GANES C. · 1994 to 2020
$35.6M
REGULATION OF INTERFERON-INDUCED DSRNA-ACTIVATED KINASER01AI034039 · NIAID · MONASH UNIVERSITY · PI WILLIAMS, BRYAN R. G. · 1993 to 2008
$2.5M
INTERFERON-REGULATED DS RNA-ACTIVATED KINASE, PKRR21AI034039 · NIAID · CLEVELAND CLINIC FOUNDATION · PI WILLIAMS, BRYAN R. G. · 1998 to 1998
–
NCI NIH HHS P01 CA062220NIAID NIH HHS R01 AI034039
6 · The paper itself

Abstract

Recent identification of key components in the pattern recognition receptor pathway of retinoic acid-inducible gene-1-like receptors, coupled with characterisation of a new cytoplasmic DNA-sensing molecule, have led to a greater understanding of the role viral nucleic acids play in activating innate immunity. This activation of type I interferon is essential for both limiting viral infection and stimulating activation of the adaptive immune response.

Identifiers

PMID20160888
PMCPMC2773505
OpenAlexW2112552390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.