ArticleMolecular systems biology2010
Revealing a signaling role of phytosphingosine-1-phosphate in yeast.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses.Journal of fungi (Basel, Switzerland) · 2023Review
- Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT.Scientific reports · 2018Article
- Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells.Cell reports · 2017Article
- The systematic analysis of protein-lipid interactions comes of age.Nature reviews. Molecular cell biology · 2015Review
- Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast.PLoS computational biology · 2015Article
- Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae.Biological research · 2015Article
- Comparative transcriptomic analysis reveals novel genes and regulatory mechanisms of Tetragenococcus halophilus in response to salt stress.Journal of industrial microbiology & biotechnology · 2015Article
- Sphingolipids and ceramides of mouse aqueous humor: Comparative profiles from normotensive and hypertensive DBA/2J mice.Biochimie · 2014Article
- Sphingolipids and lifespan regulation.Biochimica et biophysica acta · 2014Review
- The yeast sphingolipid signaling landscape.Chemistry and physics of lipids · 2014Review
- The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Molecular biology of the cell · 2014Article
- Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses.Science signaling · 2013Article
- Coordination of rapid sphingolipid responses to heat stress in yeast.PLoS computational biology · 2013Article
- Article
- Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.The Journal of biological chemistry · 2012Article
- Canonical modeling of the multi-scale regulation of the heat stress response in yeast.Metabolites · 2012Article
- Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Chemical reviews · 2011Review
- Many ceramides.The Journal of biological chemistry · 2011Review
- Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance.The Journal of biological chemistry · 2011Article
- Analysis of operating principles with S-system models.Mathematical biosciences · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Sphingolipids including sphingosine-1-phosphate and ceramide participate in numerous cell programs through signaling mechanisms. This class of lipids has important functions in stress responses; however, determining which sphingolipid mediates specific events has remained encumbered by the numerous metabolic interconnections of sphingolipids, such that modulating a specific lipid of interest through manipulating metabolic enzymes causes 'ripple effects', which change levels of many other lipids. Here, we develop a method of integrative analysis for genomic, transcriptomic, and lipidomic data to address this previously intractable problem. This method revealed a specific signaling role for phytosphingosine-1-phosphate, a lipid with no previously defined specific function in yeast, in regulating genes required for mitochondrial respiration through the HAP complex transcription factor. This approach could be applied to extract meaningful biological information from a similar experimental design that produces multiple sets of high-throughput data.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.