ReviewShock (Augusta, Ga.)2010
Fluid resuscitation: past, present, and the future.
Review in Shock (Augusta, Ga.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 255 citations in OpenAlex.
- Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials.BioMed research international · 2014Pooled it
- Trial
- Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock.Shock (Augusta, Ga.) · 2015Trial
- Acute management of spinal fractures: What you need to know.The journal of trauma and acute care surgery · 2026Review
- 4-Phenylbutyric acid extends the gold time of uncontrolled hemorrhagic shock at high altitude by alleviating vital organ injury.Intensive care medicine experimental · 2025Article
- Enhancing Trauma Care: Machine Learning-Based Photoplethysmography Analysis for Estimating Blood Volume During Hemorrhage and Resuscitation.Bioengineering (Basel, Switzerland) · 2025Article
- Influence of flow rate, fluid temperature, and extension line on Hotline and S-line heating capability: an in vitro study.BMC anesthesiology · 2021Article
- Traumatic Brain Injury-A Review of Intravenous Fluid Therapy.Frontiers in veterinary science · 2021Review
- Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model.Acta cirurgica brasileira · 2021Article
- Editorial: Fluid Therapy in Animals: Physiologic Principles and Contemporary Fluid Resuscitation Considerations.Frontiers in veterinary science · 2021Article
- Prehospital Damage Control: The Management of Volume, Temperature… and Bleeding!Colombia medica (Cali, Colombia) · 2020Review
- Fluid resuscitation in trauma: what are the best strategies and fluids?International journal of emergency medicine · 2019Review
- Resuscitation with centhaquin and 6% hydroxyethyl starch 130/0.4 improves survival in a swine model of hemorrhagic shock: a randomized experimental study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- Current Challenges in the Development of Acellular Hemoglobin Oxygen Carriers by Protein Engineering.Shock (Augusta, Ga.) · 2019Review
- Hydroxyethyl Starch 130/0.4 Binds to Neutrophils Impairing Their Chemotaxis through a Mac-1 Dependent Interaction.International journal of molecular sciences · 2019Article
- Trauma Severity and Its Impact on Local Inflammation in Extremity Injury-Insights From a Combined Trauma Model in Pigs.Frontiers in immunology · 2019Article
- Organ-Specific Oxidative Events under Restrictive Versus Full Reperfusion Following Hemorrhagic Traumatic Shock in Rats.Molecules (Basel, Switzerland) · 2018Article
- Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.Journal of neuroscience research · 2018Review
- Predictors of active arterial hemorrhage on angiography in pelvic fracture patients.Japanese journal of radiology · 2018Article
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hemorrhage remains a major cause of preventable death following both civilian and military trauma. The goals of resuscitation in the face of hemorrhagic shock are restoring end-organ perfusion and maintaining tissue oxygenation while attempting definitive control of bleeding. However, if not performed properly, resuscitation can actually exacerbate cellular injury caused by hemorrhagic shock, and the type of fluid used for resuscitation plays an important role in this injury pattern. This article reviews the historical development and scientific underpinnings of modern resuscitation techniques. We summarized data from a number of studies to illustrate the differential effects of commonly used resuscitation fluids, including isotonic crystalloids, natural and artificial colloids, hypertonic and hyperoncotic solutions, and artificial oxygen carriers, on cellular injury and how these relate to clinical practice. The data reveal that a uniformly safe, effective, and practical resuscitation fluid when blood products are unavailable and direct hemorrhage control is delayed has been elusive. Yet, it is logical to prevent this cellular injury through wiser resuscitation strategies than attempting immunomodulation after the damage has already occurred. Thus, we describe how some novel resuscitation strategies aimed at preventing or ameliorating cellular injury may become clinically available in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.