Evidence map›Paper›PMID 20160514›Full record

ReviewEpigenetics2010

Shaping the oligodendrocyte identity by epigenetic control.

Yang Yu, Patrizia Casaccia, Q Richard Lu

Abstract readReview
In one paragraph

Review in Epigenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. How to make an oligodendrocyte.Development (Cambridge, England) · 2015
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Unwrapping myelination by microRNAs.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yang YuInstitute of Stem Cell & Developmental Biology and Pediatrics Department, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
Patrizia Casaccia
Q Richard Lu

Funding

Role of cell cycle regulators in differentiationR01NS052738 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI CANOLL, PETER, CASACCIA, PATRIZIA · 2007 to 2020
$4.6M
Histone deacetylation in oligodendrocyte differentiationR01NS042925 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI CASACCIA, PATRIZIA · 2003 to 2011
$3.9M
Olig2 in Oligodendrocyte Myelination and RemyelinationR01NS050389 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LU, QING R · 2005 to 2009
$1.8M
NINDS NIH HHS NS050389NINDS NIH HHS R01 NS042925NINDS NIH HHS R01 NS050389NINDS NIH HHS R01 NS052738NINDS NIH HHS R01-NS42925NINDS NIH HHS R01-NS52738
6 · The paper itself

Abstract

Cell diversity in the central nervous system (CNS) is achieved by a highly regulated process of differentiation from multipotential neural stem cells. The spatial specificity and timing control of neural differentiation is achieved by the interplay between various genetic and epigenetic regulators. Oligodendrocytes, the myelinating cell in the CNS, play an important role in brain development and neuronal function. At present, multiple signaling pathways have been implicated in regulating in oligodendrocyte differentiation, however, the integration of these pathways with transcriptional and posttranscriptional regulatory networks are not fully understood. This review will focus on exploiting epigenetic mechanisms underlying oligodendrocyte development including chromatin remodeling by histone deacetylases and gene silencing by non-coding RNAs (e.g., microRNA), and attempts to summarize the recent advance as to the genetic and epigenetic interaction in controlling oligodendroglial differentiation and myelination.

Indexed as

Epigenesis, GeneticAnimalsHistonesHumansMicroRNAsOligodendrogliaProtein Processing, Post-TranslationalTranscription, GeneticHistonesMicroRNAs

Identifiers

PMID20160514
PMCPMC2962897

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.