ArticleAmerican journal of nephrology2010
Urinary angiotensinogen accurately reflects intrarenal Renin-Angiotensin system activity.
Article in American journal of nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 88 citations in OpenAlex.
- Trial
- Augmented Intrarenal and Urinary Angiotensinogen in Diabetic Nephropathy: The Role of Isoflavones.International journal of molecular sciences · 2025Review
- Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway.Acta pharmacologica Sinica · 2024Article
- Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis.Pediatric nephrology (Berlin, Germany) · 2023Article
- Article
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD).The Korean journal of internal medicine · 2021Article
- Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents.Archives of medical science : AMS · 2021Article
- Reduction in urinary angiotensinogen levels and improvement of proteinuria by renin-angiotensin system blockade in pediatric chronic kidney disease patients with very low birth weight.Pediatric nephrology (Berlin, Germany) · 2020Article
- Urinary angiotensinogen as a surrogate marker predicting the antiproteinuric effects of angiotensin receptor blockers in patients with overt proteinuria: a multicenter prospective study.BMC nephrology · 2020Article
- Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus.Physiological reports · 2019Article
- Enhanced angiotensinogen expression in neonates during kidney development.Clinical and experimental nephrology · 2019Article
- The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.BMC nephrology · 2018Article
- Article
- Angiotensinogen as a biomarker of acute kidney injury.Clinical kidney journal · 2017Review
- Role of the intrarenal renin-angiotensin system in the progression of renal disease.Pediatric nephrology (Berlin, Germany) · 2017Review
- Circulating and intrarenal renin-angiotensin systems in healthy men and nonpregnant women.Physiological reports · 2015Article
- Role of stimulated intrarenal angiotensinogen in hypertension.Therapeutic advances in cardiovascular disease · 2015Review
- Urinary angiotensinogen as a potential biomarker of intrarenal renin-angiotensin system activity in Chinese chronic kidney disease patients.Irish journal of medical science · 2015Article
- Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients.Pediatric nephrology (Berlin, Germany) · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWe recently reported that immunoreactivity of intrarenal angiotensinogen (AGT) is significantly increased in IgA nephropathy patients. Meanwhile, we have developed direct enzyme-linked immunosorbent assays to measure plasma and urinary AGT (UAGT) in humans. This study was performed to test the hypothesis that UAGT levels are increased in chronic glomerulonephritis patients.
methodsWe analyzed 100 urine samples from 70 chronic glomerulonephritis patients (26 from IgA nephropathy, 24 from purpura nephritis, 8 from lupus nephritis, 7 from focal segmental glomerulosclerosis, and 5 from non-IgA mesangial proliferative glomerulonephritis) and 30 normal control subjects.
resultsUAGT-creatinine ratio (UAGT/UCre) was correlated positively with diastolic blood pressure (p = 0.0326), urinary albumin-creatinine ratio (p < 0.0001), urinary protein-creatinine ratio (p < 0.0001) and urinary occult blood (p = 0.0094). UAGT/UCre was significantly increased in chronic glomerulonephritis patients not treated with renin-angiotensin system (RAS) blockers compared with control subjects (p < 0.0001). Importantly, glomerulonephritis patients treated with RAS blockers had a marked attenuation of this augmentation (p = 0.0021).
conclusionThese data indicate that UAGT are increased in chronic glomerulonephritis patients and treatment with RAS blockers suppressed UAGT. The efficacy of RAS blockade to reduce the intrarenal RAS activity can be confirmed by measurement of UAGT in chronic glomerulonephritis patients.
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