ArticleCirculation. Cardiovascular genetics2010
Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism.
Article in Circulation. Cardiovascular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.PLoS genetics · 2015Pooled it
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- Elongation of very long chain fatty acids-3 (American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Cytokine storm-based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection.JCI insight · 2023Article
- Zinc Fingers and Homeobox Family in Cancer: A Double-Edged Sword.International journal of molecular sciences · 2022Review
- ZHX2 in health and disease.Frontiers in oncology · 2022Review
- Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver.The Journal of biological chemistry · 2017Article
- Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice.PloS one · 2017Article
- Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia.Genome medicine · 2016Article
- Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.Gene expression · 2016Article
- TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner.British journal of cancer · 2015Article
- Zinc fingers and homeoboxes family in human diseases.Cancer gene therapy · 2015Review
- Article
- The complex genetic basis of plasma triglycerides.Current atherosclerosis reports · 2012Review
- Genetics of atherosclerosis.Trends in genetics : TIG · 2012Review
- Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E.Gastroenterology · 2012Article
- Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.Circulation. Cardiovascular genetics · 2012Article
- Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe previously mapped a quantitative trait locus on chromosome 15 in mice contributing to high-density lipoprotein cholesterol and triglyceride levels and now report the identification of the underlying gene. METHODS AND
resultsWe first fine-mapped the locus by studying a series of congenic strains derived from the parental strains BALB/cJ and MRL/MpJ. Analysis of gene expression and sequencing followed by transgenic complementation led to the identification of zinc fingers and homeoboxes 2 (Zhx2), a transcription factor previously implicated in the developmental regulation of alpha-fetoprotein. Reduced expression of the protein in BALB/cJ mice resulted in altered hepatic transcript levels for several genes involved in lipoprotein metabolism. Most notably, the Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase, a gene normally silenced in the adult liver, and this was normalized in BALB/cJ mice carrying the Zhx2 transgene.
conclusionsWe identified the gene underlying the chromosome 15 quantitative trait locus, and our results show that Zhx2 functions as a novel developmental regulator of key genes influencing lipoprotein metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.