ArticleProceedings of the National Academy of Sciences of the United States of America2010
Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A cadherin-integrin-ECM code for presomitic mesoderm fluidity.Development (Cambridge, England) · 2025Article
- The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Biomolecules · 2025Review
- A transcriptional and regulatory map of mouse somite maturation.Developmental cell · 2023Article
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Time and space in segmentation.Interface focus · 2021Article
- ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.Journal of molecular and cellular cardiology · 2020Review
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- PPARβ/δ: Linking Metabolism to Regeneration.International journal of molecular sciences · 2018Review
- Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.Developmental cell · 2017Article
- A Gradient of Glycolytic Activity Coordinates FGF and Wnt Signaling during Elongation of the Body Axis in Amniote Embryos.Developmental cell · 2017Article
- In Vivo Human Somitogenesis Guides Somite Development from hPSCs.Cell reports · 2017Article
- The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure.Cell metabolism · 2016Article
- Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics.Stem cells (Dayton, Ohio) · 2016Article
- Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.Nature biotechnology · 2015Article
- Signalling dynamics in vertebrate segmentation.Nature reviews. Molecular cell biology · 2014Review
- Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves.Development (Cambridge, England) · 2014Article
- Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo.Development (Cambridge, England) · 2014Article
- Manteia, a predictive data mining system for vertebrate genes and its applications to human genetic diseases.Nucleic acids research · 2014Article
- Cited3 activates Mef2c to control muscle cell differentiation and survival.Biology open · 2013Article
- A genome-wide screen indicates correlation between differentiation and expression of metabolism related genes.PloS one · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The development of multicellular organisms is controlled by transcriptional networks. Understanding the role of these networks requires a full understanding of transcriptome regulation during embryogenesis. Several microarray studies have characterized the temporal evolution of the transcriptome during development in different organisms [Wang QT, et al. (2004) Dev Cell 6:133-144; Furlong EE, Andersen EC, Null B, White KP, Scott MP (2001) Science 293:1629-1633; Mitiku N, Baker JC (2007) Dev Cell 13:897-907]. In all cases, however, experiments were performed on whole embryos, thus averaging gene expression among many different tissues. Here, we took advantage of the local synchrony of the differentiation process in the paraxial mesoderm. This approach provides a unique opportunity to study the systems-level properties of muscle differentiation. Using high-resolution, spatiotemporal profiling of the early stages of muscle development in the zebrafish embryo, we identified a major reorganization of the transcriptome taking place in the presomitic mesoderm. We further show that the differentiation process is associated with a striking modular compartmentalization of the transcription of essential components of cellular physiological programs. Particularly, we identify a tight segregation of cell cycle/DNA metabolic processes and translation/oxidative metabolism at the tissue level, highly reminiscent of the yeast metabolic cycle. These results should expand more investigations into the developmental control of metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.