ArticleInfection and immunity2010
The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 118 citations in OpenAlex.
- Temporal dynamics of gut biosynthetic gene clusters link persistent colonization and engraftment in fecal microbiota transplantation.Gut microbes · 2026Article
- Environmental and Host Blood Interactions ShapePathogens (Basel, Switzerland) · 2026Article
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- Siderophore systems at play: system interactions as drivers of diversification in pathogenicmBio · 2025Article
- Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease.Cell host & microbe · 2025Article
- The Role of Bacterial Siderophores in Infection Therapy: From Anti-Infective Mechanisms to Therapeutic Advances.International journal of nanomedicine · 2025Review
- Transovarial transmission of Yersinia pestis in its flea vector Xenopsylla cheopis.Nature communications · 2024Article
- Different characteristics of the soil in marmot habitats might be one of the factors that influctingFrontiers in microbiology · 2024Article
- Non-classical roles of bacterial siderophores in pathogenesis.Frontiers in cellular and infection microbiology · 2024Review
- Transovarial transmission of Yersinia pestis in its flea vector, Xenopsylla cheopis.Research square · 2023Article
- Droplet Tn-Seq identifies the primary secretion mechanism for yersiniabactin in Yersinia pestis.EMBO reports · 2023Article
- Genomic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Overview ofBiology · 2023Review
- A frameshift ineLife · 2023Article
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- Priority Effects in the Apple Flower Determine If the Siderophore Desferrioxamine Is a Virulence Factor for Erwinia amylovora CFBP1430.Applied and environmental microbiology · 2022Article
- Microenvironmental Factors that Shape Bacterial Metabolites in Inflammatory Bowel Disease.Frontiers in cellular and infection microbiology · 2022Review
- Attenuation ofFrontiers in cellular and infection microbiology · 2022Article
- Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.Nature communications · 2021Article
- Yersiniabactin contributes to overcoming zinc restriction duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Iron acquisition from the host is an important step in the pathogenic process. While Yersinia pestis has multiple iron transporters, the yersiniabactin (Ybt) siderophore-dependent system plays a major role in iron acquisition in vitro and in vivo. In this study, we determined that the Ybt system is required for the use of iron bound by transferrin and lactoferrin and examined the importance of the Ybt system for virulence in mouse models of bubonic and pneumonic plague. Y. pestis mutants unable to either transport Ybt or synthesize the siderophore were both essentially avirulent via subcutaneous injection (bubonic plague model). Surprisingly, via intranasal instillation (pneumonic plague model), we saw a difference in the virulence of Ybt biosynthetic and transport mutants. Ybt biosynthetic mutants displayed an approximately 24-fold-higher 50% lethal dose (LD(50)) than transport mutants. In contrast, under iron-restricted conditions in vitro, a Ybt transport mutant had a more severe growth defect than the Ybt biosynthetic mutant. Finally, a Delta pgm mutant had a greater loss of virulence than the Ybt biosynthetic mutant, indicating that the 102-kb pgm locus encodes a virulence factor, in addition to Ybt, that plays a role in the pathogenesis of pneumonic plague.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.