ArticleThe Journal of biological chemistry2010
Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Copper Dyshomeostasis Affects α-Synuclein Clearance Mechanisms in Parkinson's Disease: Insights from In Vitro Models and Translational Evidence.International journal of molecular sciences · 2026Review
- Ubiquitin-elongating enzyme Ufd2 confers resistance to hygromycin B inmicroPublication biology · 2026Article
- The Dsc complex and its role in Golgi quality control.Biochemical Society transactions · 2024Review
- Review
- E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response.Molecular cell · 2023Article
- Ubiquitination in the ERAD Process.International journal of molecular sciences · 2020Review
- Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope.Seminars in cell & developmental biology · 2019Review
- UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.Nature communications · 2018Article
- Sumoylation, Phosphorylation, and Acetylation Fine-Tune the Turnover of Plant Immunity Components Mediated by Ubiquitination.Frontiers in plant science · 2017Review
- Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.The Journal of biological chemistry · 2016Article
- E4-Ubiquitin ligase Ufd2 stabilizes Yap8 and modulates arsenic stress responses independent of the U-box motif.Biology open · 2015Article
- Review
- Cdc48: a swiss army knife of cell biology.Journal of amino acids · 2013Review
- The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation.The Journal of biological chemistry · 2012Article
- Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation.Seminars in cell & developmental biology · 2012Review
- Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.The Journal of biological chemistry · 2011Article
- Type 2 deiodinase at the crossroads of thyroid hormone action.The international journal of biochemistry & cell biology · 2011Review
- The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.Molecular and cellular biology · 2011Article
- The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.Nature cell biology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Ufd2 is the founding member of E4 enzymes that are specifically involved in ubiquitin chain elongation but whose roles in proteolysis remain scarce. Here, using a genome-wide screen, we identified one cellular target of yeast Ufd2 as the membrane protein Pex29. The ubiquitin chains assembled on Pex29 in vivo by Ufd2 mainly contain Lys-48 linkages. We found that the ubiquitin-protein E3 ligase for overexpressed Pex29 is Doa10, which is known to be involved in protein quality control. Interestingly, not all Doa10 substrates are regulated by Ufd2, suggesting that E4 involvement is not specific to a particular E3, but may depend on the spatial arrangement of the E3-substrate interaction. Cells lacking UFD2 elicit an unfolded protein response, expanding the physiological function of Ufd2. Our results lead to novel insights into the biological role of Ufd2 and further underscore the significance of Ufd2 in proteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.