ArticleThe Journal of biological chemistry2010
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Current and future therapies for small cell lung carcinoma.Journal of hematology & oncology · 2025Review
- CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection.Nature microbiology · 2024Article
- Article
- Analysis of the role of acetylation inFrontiers in microbiology · 2024Article
- Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites.mSphere · 2021Article
- Emerging Therapeutic Targets AgainstFrontiers in cellular and infection microbiology · 2020Review
- Global Lysine Crotonylation and 2-Hydroxyisobutyrylation in Phenotypically DifferentMolecular & cellular proteomics : MCP · 2019Article
- Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Frontiers in cellular and infection microbiology · 2019Article
- Supplementing Genistein for Breeder Hens Alters the Fatty Acid Metabolism and Growth Performance of Offsprings by Epigenetic Modification.Oxidative medicine and cellular longevity · 2019Article
- Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New.Trends in parasitology · 2018Review
- Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii.Antimicrobial agents and chemotherapy · 2016Article
- DNA damage regulation and its role in drug-related phenotypes in the malaria parasites.Scientific reports · 2016Article
- The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii.Frontiers in microbiology · 2016Review
- HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani.Nucleic acids research · 2015Article
- Albendazole induces oxidative stress and DNA damage in the parasitic protozoan Giardia duodenalis.Frontiers in microbiology · 2015Article
- Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii.The Journal of biological chemistry · 2013Article
- Histones: Controlling Tumor Signaling Circuitry.Journal of carcinogenesis & mutagenesis · 2013Article
- Toxoplasma histone acetylation remodelers as novel drug targets.Expert review of anti-infective therapy · 2012Review
- Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.Eukaryotic cell · 2012Article
- Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Antimicrobial agents and chemotherapy · 2012Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The MYST family of lysine acetyltransferases (KATs) function in a wide variety of cellular operations, including gene regulation and the DNA damage response. Here we report the characterization of the second MYST family KAT in the protozoan parasite Toxoplasma gondii (TgMYST-B). Toxoplasma causes birth defects and is an opportunistic pathogen in the immunocompromised, the latter due to its ability to convert into a latent cyst (bradyzoite). We demonstrate that TgMYST-B can gain access to the parasite nucleus and acetylate histones. Overexpression of recombinant, tagged TgMYST-B reduces growth rate in vitro and confers protection from a DNA-alkylating agent. Expression of mutant TgMYST-B produced no growth defect and failed to protect against DNA damage. We demonstrate that cells overexpressing TgMYST-B have increased levels of ataxia telangiectasia mutated (ATM) kinase and phosphorylated H2AX and that TgMYST-B localizes to the ATM kinase gene. Pharmacological inhibitors of ATM kinase or KATs reverse the slow growth phenotype seen in parasites overexpressing TgMYST-B. These studies are the first to show that a MYST KAT contributes to ATM kinase gene expression, further illuminating the mechanism of how ATM kinase is up-regulated to respond to DNA damage.
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Registered trials
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