ArticleJournal of cell science2010
Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 159 citations in OpenAlex.
- Is SIRT3 and Mitochondria a Reliable Target for Parkinson's Disease and Aging? A Narrative Review.Molecular neurobiology · 2025Review
- Role of NADCellular and molecular neurobiology · 2023Review
- Article
- Real-time resolution studies of the regulation of pyruvate-dependent lactate metabolism by hexokinases in single cells.PloS one · 2023Article
- Emerging Roles of SIRT3 in Cardiac Metabolism.Frontiers in cardiovascular medicine · 2022Review
- Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1Molecular neurobiology · 2021Article
- MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.Circulation · 2018Article
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.Chemical reviews · 2018Review
- Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart.Pflugers Archiv : European journal of physiology · 2017Article
- Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?Cellular and molecular life sciences : CMLS · 2017Review
- Mitochondrial CaJournal of bioenergetics and biomembranes · 2017Review
- Anion Channels of Mitochondria.Handbook of experimental pharmacology · 2017Review
- Post-translational modifications in mitochondria: protein signaling in the powerhouse.Cellular and molecular life sciences : CMLS · 2016Review
- Sprague Dawley rats: A model of successful heart aging.EuPA open proteomics · 2016Article
- Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Cellular and molecular life sciences : CMLS · 2016Review
- Potential Benefit of the Charge-Stabilized Nanostructure Saline RNS60 for Myelin Maintenance and Repair.Scientific reports · 2016Article
- Article
- Mechanisms and Dynamics of Protein Acetylation in Mitochondria.Trends in biochemical sciences · 2016Review
- Alcoholic pancreatitis: New insights into the pathogenesis and treatment.World journal of gastrointestinal pathophysiology · 2016Review
- SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.The Journal of biological chemistry · 2016Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Expression of concern · 2016-02-15Concerns/Issues about Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Objections by Third Party · · This EoC is upgraded by PMID:27369360, citing Misconduct by John G Pastorino;
- Retraction · 2016-07-01Duplication of/in Image · Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by Journal/Publisher · Investigation by ORI · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Third Party · Upgrade/Update of Prior Notice(s) · · Misconduct by John G Pastorino; Expression of Concern at PMID: 26905965;
- Commented on by
- Commented on by
- Expression of concern
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We demonstrate that the transition from a reliance on glycolysis to oxidative phosphorylation in a transformed cell line is dependent on an increase in the levels and activity of sirtuin-3. Sirtuin-3 deacetylates cyclophilin D, diminishing its peptidyl-prolyl cis-trans isomerase activity and inducing its dissociation from the adenine nucleotide translocator. Moreover, the sirtuin-3-induced inactivation of cyclophilin D causes a detachment of hexokinase II from the mitochondria that is necessary for stimulation of oxidative phosphorylation. These results might have important implications for the role of sirtuin-3 in the metabolism of some cancer cells and their susceptibility to mitochondrial injury and cytotoxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.