Evidence map›Paper›PMID 20159820›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2010

Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women.

Christine M Friedenreich, Christy G Woolcott, Anne McTiernan, Rachel Ballard-Barbash, Rollin F Brant, Frank Z Stanczyk, Tim Terry, Norman F Boyd, Martin J Yaffe, Melinda L Irwin and 7 more

2 registry-linked trialsOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 105 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 10 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00522262 nacompletednot on this map

Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial

TypeinterventionalSponsorAHS Cancer Control AlbertaRan2002 to 2007Enrolled320ConditionsBreast NeoplasmsArmsAerobic exercise intervention
NCT02240836 naactive not recruitingnot on this mapstarted 2014, after this paper: background citation

Energy Balance and Breast Cancer Aspects-II Study

TypeinterventionalSponsorOslo University HospitalRan2014 to 2027Enrolled545ConditionsDCIS Grade 3, Stage I Breast Cancer, Stage II Breast Cancer, LCIS, Lobular Carcinoma in SituArmsIntervention. Exercise
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 10 syntheses or guidelines pooled it, 223 citations in OpenAlex.

  1. Pooled it
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  5. Atencion primaria · 2018
    Guideline
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  12. A Co-clinical Trial of Exercise Therapy in Breast Cancer Prevention.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Christine M FriedenreichAlberta Health Services, Calgary, Alberta, Canada. christine.friedenreich@albertahealthservices.ca
Christy G Woolcott
Anne McTiernan
Rachel Ballard-Barbash
Rollin F Brant
Frank Z Stanczyk
Tim Terry
Norman F Boyd
Martin J Yaffe
Melinda L Irwin
Charlotte A Jones
Yutaka Yasui
Kristin L Campbell
Margaret L McNeely
Kristina H Karvinen
Qinggang Wang
Kerry S Courneya
Alberta Health Services · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe examined how an aerobic exercise intervention influenced circulating estradiol, estrone, sex hormone-binding globulin (SHBG), androstenedione, and testosterone levels, which may be involved in the association between physical activity and breast cancer risk.

methodsA two-center, two-arm randomized controlled trial of exercise was conducted in 320 postmenopausal, sedentary women age 50 to 74 years. Participants were randomly assigned to a 1-year aerobic exercise intervention of 225 min/wk (n = 160) or to a control group who maintained their usual level of activity (n = 160). Baseline, 6-month, and 12-month assessments of estrone, estradiol, androstenedione, and testosterone were quantified by radioimmunoassay after extraction, and SHBG was quantified by an immunometric assay. Intent-to-treat analyses were performed using linear mixed models.

resultsBlood data were available on 309 women (96.6%) at 12 months. Women in the intervention group exercised an average of 3.6 d/wk for 178 min/wk. At 12 months, statistically significant reductions in estradiol (treatment effect ratio [TER] = 0.93; 95% CI, 0.88 to 0.98) and free estradiol (TER = 0.91; 95% CI, 0.87 to 0.96) and increases in SHBG (TER = 1.04; 95% CI, 1.02 to 1.07) were observed in the exercise group compared with the control group. No significant differences in estrone, androstenedione, and testosterone levels were observed between exercisers and controls at 12 months.

conclusionThis trial found that previously sedentary postmenopausal women can adhere to a moderate- to vigorous-intensity exercise program that results in changes in estradiol and SHBG concentrations that are consistent with a lower risk for postmenopausal breast cancer.

Indexed as

AgedAndrostenedioneBreast NeoplasmsEstradiolEstroneExerciseFemaleHumansMiddle AgedPostmenopauseRiskSex Hormone-Binding GlobulinTestosteroneAndrostenedioneEstradiolEstroneSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID20159820
PMCPMC2849767
OpenAlexW2158234071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.