ArticleCell host & microbe2010
Modeling antibody-enhanced dengue virus infection and disease in mice: protection or pathogenesis?
Article in Cell host & microbe, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Review
- Post-Vaccination Yellow Fever Antiserum Reduces Zika Virus in Embryoid Bodies When Placental Cells are Present.Vaccines · 2020Article
- Strain-Dependent Activity of Zika Virus and Exposure History in Serological Diagnostics.Tropical medicine and infectious disease · 2020Article
- The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis.PLoS pathogens · 2019Review
- Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.Scientific reports · 2018Article
- Viral-Induced Enhanced Disease Illness.Frontiers in microbiology · 2018Review
- New insights into the immunopathology and control of dengue virus infection.Nature reviews. Immunology · 2015Review
- Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.Journal of virology · 2015Article
- An Epitope-Substituted DNA Vaccine Improves Safety and Immunogenicity against Dengue Virus Type 2.PLoS neglected tropical diseases · 2015Article
- The role of viral persistence in flavivirus biology.Pathogens and disease · 2014Review
- Subneutralizing antibodies to enterovirus 71 induce antibody-dependent enhancement of infection in newborn mice.Medical microbiology and immunology · 2013Article
- Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection.Journal of virology · 2012Article
- Subversion of innate defenses by the interplay between DENV and pre-existing enhancing antibodies: TLRs signaling collapse.PLoS neglected tropical diseases · 2010Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
While antibodies play an important protective role during dengue virus infection, they have also been linked to more severe clinical outcomes. In this issue of Cell Host & Microbe, Zellweger and colleagues (Zellweger et al., 2010) describe the development of a murine model of antibody-enhanced dengue virus infection that provides a formal link between immune enhancement and severe disease.
Identifiers
20159612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.