ArticleCancer cell2010
Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link.
Article in Cancer cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.PloS one · 2012Pooled it
- Differential in vitro effects of targeted therapeutics in primary human liver cancer: importance for combined liver cancer.BMC cancer · 2022Article
- Nod2 protects mice from inflammation and obesity-dependent liver cancer.Scientific reports · 2020Article
- Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats.Acta pharmaceutica Sinica. B · 2020Article
- The contribution of miR-122 to the innate immunity by regulating toll-like receptor 4 in hepatoma cells.BMC gastroenterology · 2019Article
- Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma.Cancer research and treatment · 2019Article
- Comprehensive molecular and immunological characterization of hepatocellular carcinoma.EBioMedicine · 2019Article
- Article
- Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma.Oncotarget · 2017Review
- Review
- Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.Molecular cancer therapeutics · 2017Article
- p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.Cancer cell · 2016Article
- Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension.The Journal of biological chemistry · 2016Article
- IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma.Oncotarget · 2016Article
- ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.Cancer cell · 2014Article
- Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- CellMinerHCC: a microarray-based expression database for hepatocellular carcinoma cell lines.Liver international : official journal of the International Association for the Study of the Liver · 2014Article
- Mining cancer-specific disease comorbidities from a large observational health database.Cancer informatics · 2014Article
- STAT3 in hepatocellular carcinoma: new perspectives.Hepatic oncology · 2014Review
- Inhibition of autocrine IGF-II on effect of human HepG2 cell proliferation and angiogenesis factor expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.