ArticleDevelopmental cell2010
Structural basis of selective ubiquitination of TRF1 by SCFFbx4.
Article in Developmental cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- CDK2-mediated phosphorylation of TRF1 S11 facilitates DNA damage repair by remodeling telomeric chromatin.Cell death and differentiation · 2026Article
- Degrons and degradation signals beyond short linear motifs.Nature chemical biology · 2026Review
- Protein degradation: expanding the toolbox to restrain cancer drug resistance.Journal of hematology & oncology · 2023Review
- The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives.Cancers · 2022Review
- Review
- E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.SLAS discovery : advancing life sciences R & D · 2021Review
- Cyclin D degradation by E3 ligases in cancer progression and treatment.Seminars in cancer biology · 2020Review
- Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential.Cancers · 2020Review
- FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.Nucleic acids research · 2019Article
- Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.Cell research · 2017Article
- Maintenance of telomere length in AML.Blood advances · 2017Review
- Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.Nature communications · 2017Article
- Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Molecular cell · 2017Article
- Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction.Frontiers in genetics · 2017Review
- Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1.Biochemistry · 2015Article
- The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation.Molecular and cellular biology · 2015Article
- The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.Molecular and cellular biology · 2013Article
- Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Mechanisms and function of substrate recruitment by F-box proteins.Nature reviews. Molecular cell biology · 2013Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes to substrate specification. Here, we report the crystal structure of the Fbx4-TRF1 complex at 2.4 A resolution. Fbx4 contains an unusual substrate-binding domain that adopts a small GTPase fold. Strikingly, this atypical GTPase domain of Fbx4 binds to a globular domain of TRF1 through an intermolecular beta sheet, instead of recognizing short peptides/degrons as often seen in other F-box protein-substrate complexes. Importantly, mutations in this interface abrogate Fbx4-dependent TRF1 binding and ubiquitination. Furthermore, the data demonstrate that recognition of TRF1 by SCF(Fbx4) is regulated by another telomere protein, TIN2. Our results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.