ArticleMolecular cell2010
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.
Article in Molecular cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 429 papers.
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Who cites it
429 citing papers in PubMed, 987 citations in OpenAlex.
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- A Comprehensive Review on Engineering Release at the Molecular Level: Role of Functional Groups in Polysaccharide-Based Drug Delivery.Materials (Basel, Switzerland) · 2026Review
- Positive epistasis among ribosomal mutations drives high-level streptomycin resistance inApplied and environmental microbiology · 2026Article
- Aminotetrazole-Gold Nanocomplexes Shunt Electrons to Eradicate Bacteria Without ROS-Induced Resistance.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ciprofloxacin-Based Ionic Liquids Increase Mutation Frequency inAntibiotics (Basel, Switzerland) · 2026Article
- Redox stress agents strongly enhance mutagenesis during horizontal gene transfer in bacteria and leave distinct mutational and metabolic footprints.bioRxiv : the preprint server for biology · 2026Article
- Antimicrobial-resistant Escherichia Coli and Salmonella in poultry production and spread and effect in the one health framework.Poultry science · 2026Review
- High Resistance and Biofilm Tolerance to Antimicrobials of Marine Bacteria From Brazilian Deep-Sea Sediment.Environmental microbiology reports · 2026Article
- Reduced ROS-associated prophage induction in a lepA mutant contributes to increased fluoroquinolone persistence in Salmonella Typhimurium.Scientific reports · 2026Article
- The Role of the SOS Response in the Adaptation ofCurrent issues in molecular biology · 2026Review
- Dietary copper-driven colonic dysbiosis mediates oxidative stress and butyrate deficiency to facilitate the spread of resistome in pigs.NPJ biofilms and microbiomes · 2026Article
- Evolutionary adaptations ofMicrobiology spectrum · 2026Article
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- Advancements in Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia as a Promising Strategy to Combat Antibacterial Resistance.International journal of nanomedicine · 2026Review
- Roles of micro/nanoplastics in the spread of antimicrobial resistance through conjugative gene transfer.Nature communications · 2025Article
- Article
369 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Antibiotic resistance arises through mechanisms such as selection of naturally occurring resistant mutants and horizontal gene transfer. Recently, oxidative stress has been implicated as one of the mechanisms whereby bactericidal antibiotics kill bacteria. Here, we show that sublethal levels of bactericidal antibiotics induce mutagenesis, resulting in heterogeneous increases in the minimum inhibitory concentration for a range of antibiotics, irrespective of the drug target. This increase in mutagenesis correlates with an increase in ROS and is prevented by the ROS scavenger thiourea and by anaerobic conditions, indicating that sublethal concentrations of antibiotics induce mutagenesis by stimulating the production of ROS. We demonstrate that these effects can lead to mutant strains that are sensitive to the applied antibiotic but resistant to other antibiotics. This work establishes a radical-based molecular mechanism whereby sublethal levels of antibiotics can lead to multidrug resistance, which has important implications for the widespread use and misuse of antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.