Evidence map›Paper›PMID 20159507›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2010

Adolescent offspring of mothers with chronic fatigue syndrome.

Mark S Smith, Dedra S Buchwald, Andy Bogart, Jack Goldberg, Wayne R Smith, Niloofar Afari

Abstract readComparative Study
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mark S SmithDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Dedra S Buchwald
Andy Bogart
Jack Goldberg
Wayne R Smith
Niloofar Afari
University of Washington · USVA San Diego Healthcare System · US

Funding

ZIPRASIDONE IN NORMAL HEPATIC FUNCTION SUBJECTS &IN HEPATIC DYSFUCTIN SUBJECTSM01RR000037 · NCRR · UNIVERSITY OF WASHINGTON · PI MCDONALD, RUTH C · 1985 to 2007
$33.8M
PROGNOSIS OF CHRONIC FATIGUE SYNDROMEU19AI038429 · NIAID · UNIVERSITY OF WASHINGTON · PI SULLIVAN, PATRICK F · 1995 to 2002
$2.8M
Twin Study of Chronic Widespread PainR01AR051524 · NIAMS · UNIVERSITY OF WASHINGTON · PI AFARI, NILOOFAR · 2005 to 2009
$1.8M
NCRR NIH HHS M01 RR000037NCRR NIH HHS M01RR-00037NIAID NIH HHS AI-038429NIAID NIH HHS U19 AI038429NIAMS NIH HHS R01 AR051524NIAMS NIH HHS R01AR051524
6 · The paper itself

Abstract

purposeThe goal of this study was to determine whether adolescent offspring of mothers with chronic fatigue syndrome (CFS) have higher prevalence of CFS and report more fatigue, greater pain sensitivity, more sleep problems, and poorer cardiopulmonary fitness in comparison with offspring with no exposure to maternal CFS.

methodsA total of 26 adolescent offspring of 20 mothers diagnosed with CFS were compared with 45 adolescent offspring of 30 age-matched healthy control mothers. Study measures included structured interviews and medical and laboratory examinations for CFS; tender point examination; maximum oxygen uptake and perceived exertion; dolorimetry pain ratings; and questionnaires on fatigue severity and sleepiness.

resultsIn comparison with offspring of healthy mothers, those exposed to mothers with CFS reported higher prevalence of fatigue of at least 1-month duration (23% vs. 4%), fatigue of 6 months or longer (15% vs. 2%), and met criteria for CFS (12% vs. 2%), although these differences only approached statistical significance. CFS and healthy mothers differed on almost all study outcomes, but offspring groups did not differ on measures of current fatigue severity, pain sensitivity, sleep, mean number of tender points, and cardiopulmonary fitness.

conclusionsThe higher prevalence of fatiguing states in offspring of CFS mothers, despite the lack of statistical significance, suggests that familial factors may potentially play a role in developing chronically fatiguing states. Alternately, perturbations in pain sensitivity and cardiopulmonary fitness may be consequences of CFS. Future studies should focus on examining the impact of maternal CFS and associated disability on psychosocial functioning of offspring.

Indexed as

Child of Impaired ParentsAdolescentAdultFatigue Syndrome, ChronicFemaleHumansInterviews as TopicMaleMiddle AgedPhysical FitnessSurveys and QuestionnairesWashington

Identifiers

PMID20159507
PMCPMC2824612
OpenAlexW2139205950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.