ReviewThe Psychiatric clinics of North America2010
Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization.
Review in The Psychiatric clinics of North America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 79 citations in OpenAlex.
- [The German research network for mental disorders].Der Nervenarzt · 2016Article
- Neural correlates of hallucinations in bipolar disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2016Article
- Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders.Metabolic brain disease · 2016Article
- Molecular actions and clinical pharmacogenetics of lithium therapy.Pharmacology, biochemistry, and behavior · 2014Review
- Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2014Article
- Neurocognitive features in subgroups of bipolar disorder.Bipolar disorders · 2013Article
- Diagnosing bipolar disorders in DSM-5.International journal of bipolar disorders · 2013Article
- Maternal perspectives on the return of genetic results: context matters.American journal of medical genetics. Part A · 2013Article
- Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats.In silico pharmacology · 2013Article
- Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder.International journal of bipolar disorders · 2013Article
- Managing sensitive phenotypic data and biomaterial in large-scale collaborative psychiatric genetic research projects: practical considerations.Molecular psychiatry · 2012Article
- Developmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation.Translational psychiatry · 2012Article
- Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II.Journal of child psychology and psychiatry, and allied disciplines · 2012Article
- Response to treatment in bipolar disorder.Current opinion in psychiatry · 2011Review
- [Bipolar depression. Epidemiology, etiopathogenesis, and course].Der Nervenarzt · 2010Article
- Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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1 author at 1 institution in 2 countries.
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Abstract
Research into the genetic basis of bipolar disorder (BD) has reached a turning point. Genome-wide association studies (GWAS), encompassing several thousand samples, have produced replicated evidence for some novel susceptibility genes; however, the genetic variants implicated so far account for only a fraction of disease liability, a phenomenon not limited to psychiatric phenotypes but characteristic of all complex genetic traits studied to date. It appears that pure genomic approaches, such as GWAS alone, will not suffice to unravel the genetic basis of a complex illness like BD. Genomic approaches will need to be complemented by a variety of strategies, including phenomics, epigenomics, pharmacogenomics, and neurobiology, as well as the study of environmental factors. This review highlights the most promising findings from recent GWAS and candidate gene studies in BD. It furthermore sketches out a potential research framework integrating various lines of research into the molecular biological basis of BD.
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